Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.57 |
| ▸ | PTPRB | P23467 | 1/20 | 0.54 |
| ▸ | CDC25A | P30304 | 1/20 | 0.54 |
| ▸ | CDC25B | P30305 | 1/20 | 0.54 |
| ▸ | PTEN | P60484 | 1/20 | 0.54 |
| ▸ | PTPMT1 | Q8WUK0 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
| ▸ | PLA2G10 | O15496 | 6/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.48 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4407150 | 0.87 | KEAP1 (0.63) | KEAP1PTPRBCDC25ACDC25BPTEN | |
| SCHEMBL30638471 | 0.87 | KEAP1 (0.63) | KEAP1PTPRBCDC25ACDC25BPTEN | |
| SCHEMBL70271 | 0.87 | KEAP1 (0.74) | KEAP1PTPRBCDC25ACDC25BPTEN | |
| SCHEMBL21728869 | 0.85 | AKR1B1 (0.58) | ITGB3ITGA2BPLA2G10PLA2G2A | |
| Hydrochloric Acid SCHEMBL10982620 | 0.85 | KEAP1 (0.71) | KEAP1PTPRBCDC25ACDC25BPTEN | |
| SCHEMBL10339219 | 0.84 | CA2 (0.54) | MAPK1 | |
| SCHEMBL18798802 | 0.82 | LMNA (0.50) | HDAC3MAPK1ADRA1AHDAC4SLC6A3 | |
| SCHEMBL2016247 | 0.81 | KEAP1 (0.61) | KEAP1PTPRBCDC25ACDC25BPTEN | |
| SCHEMBL31273986 | 0.81 | KEAP1 (0.61) | KEAP1PTPRBCDC25ACDC25BPTEN | |
| SCHEMBL5264276 | 0.81 | KEAP1 (0.61) | KEAP1PTPRBCDC25ACDC25BPTEN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658667-A1 | CYCLIC PEPTIDES FOR INHIBITING TNF RECEPTOR 1 ACTIVITY | Merck Sharp & Dohme LLC (US) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024163691-A1 | CYCLIC PEPTIDES FOR INHIBITING TNF RECEPTOR 1 ACTIVITY | MERCK SHARP & DOHME LLC (US) | 2024-08-08 | — | — | WO | disclosed |
| CN-102083432-A | Acylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals | SANOFI AVENTIS | 2011-06-01 | — | — | CN | disclosed |
| CN-85101711-A | The preparation new cephalosporins and process for their | — | 1987-01-31 | — | — | CN | disclosed |