Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544711 | 0.80 | GAA (0.44) | POLBHDAC6ALDH1A1HTTL3MBTL1 | |
| SCHEMBL11789572 | 0.78 | ALDH1A1 (0.41) | HDAC6ALDH1A1HTTL3MBTL1GAA | |
| SCHEMBL1315041 | 0.77 | ROCK2 (0.37) | ALDH1A1L3MBTL1GAALMNAKDM4E | |
| SCHEMBL5049141 | 0.77 | CXCR2 (0.41) | POLBALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL31612303 | 0.77 | ALDH1A1 (0.40) | HDAC6ALDH1A1HTTL3MBTL1GAA | |
| SCHEMBL28617457 | 0.75 | MAPK3 (0.43) | HDAC6ALDH1A1HTTL3MBTL1GAA | |
| SCHEMBL8378409 | 0.75 | PDK1 (0.41) | HDAC6ALDH1A1HTTL3MBTL1GAA | |
| SCHEMBL28679627 | 0.75 | ALDH1A1 (0.39) | HDAC6ALDH1A1HTTL3MBTL1GAA | |
| SCHEMBL13806415 | 0.75 | HDAC6 (0.40) | HDAC6ALDH1A1HTTL3MBTL1GAA | |
| SCHEMBL3989842 | 0.75 | HDAC6 (0.40) | HDAC6ALDH1A1HTTL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101014343-A | Tetracyclic lactam derivatives and uses thereof | INOTEK PHARMACEUTICALS CORP (US) | 2007-08-08 | — | — | CN | disclosed |