Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HK1 | P19367 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GALK1 | P51570 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27707619 | 0.71 | GRIA1 (0.37) | RAB9ACYP1A2 | |
| SCHEMBL31462459 | 0.69 | BCL2L1 (0.33) | — | |
| SCHEMBL430954 | 0.68 | GABRA1 (0.38) | MEN1KMT2AKDM4ENPC1HSP90AA1 | |
| SCHEMBL3621915 | 0.63 | PARP1 (0.43) | KDM4ENPC1MAPTALDH1A1 | |
| SCHEMBL88725 | 0.62 | MEN1 (0.65) | MEN1KMT2AKDM4ENPC1HSP90AA1 | |
| SCHEMBL28379837 | 0.62 | HTR5A (0.42) | MEN1KMT2AKDM4ENPC1HSP90AA1 | |
| SCHEMBL9833949 | 0.62 | MEN1 (0.48) | MEN1KMT2AKDM4ENPC1HSP90AA1 | |
| SCHEMBL17591558 | 0.61 | NFE2L2 (0.41) | MEN1KMT2AKDM4EMAPTTHRB | |
| SCHEMBL333121 | 0.61 | NFE2L2 (0.41) | MEN1KMT2AKDM4EMAPTTHRB | |
| SCHEMBL333122 | 0.61 | NFE2L2 (0.41) | MEN1KMT2AKDM4EMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101048414-B | Fused tricyclic derivatives for the treatment of psychotic disorders | GLAXO GROUP LTD | 2011-09-07 | — | — | CN | disclosed |
| CN-101048414-A | Fused tricyclic derivatives for the treatment of psychotic disorders | GLAXO GROUP LTD (GB) | 2007-10-03 | — | — | CN | disclosed |