Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.53 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL726400 | 0.83 | CTNNB1 (0.57) | KDM4EALDH1A1SMN1; SMN2PARP10KMT2A | |
| SCHEMBL20176683 | 0.82 | RAB9A (0.43) | KDM4EALDH1A1SMN1; SMN2LMNAPARP10 | |
| SCHEMBL27603077 | 0.77 | RAB9A (0.70) | KDM4EALDH1A1SMN1; SMN2LMNAPARP10 | |
| SCHEMBL2562259 | 0.76 | CTNNB1 (0.70) | KDM4EALDH1A1SMN1; SMN2LMNAPARP10 | |
| SCHEMBL27711531 | 0.74 | SMN1; SMN2 (0.44) | KDM4ESMN1; SMN2PARP10KMT2AMAPT | |
| SCHEMBL27564839 | 0.72 | CTNNB1 (0.51) | KDM4EALDH1A1SMN1; SMN2PARP10KMT2A | |
| SCHEMBL22159054 | 0.72 | ALDH1A1 (0.55) | KDM4EALDH1A1SMN1; SMN2LMNAPARP10 | |
| SCHEMBL3693404 | 0.72 | PARP10 (0.50) | KDM4EALDH1A1SMN1; SMN2LMNAPARP10 | |
| SCHEMBL5971792 | 0.72 | SMN1; SMN2 (0.42) | KDM4EALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL8311249 | 0.72 | TTR (0.58) | KDM4EALDH1A1SMN1; SMN2LMNAPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2208727-A1 | Diaryl ethers as opioid receptor antagonist | Eli Lilly & Company (US) | 2010-07-21 | — | — | EP | disclosed |
| US-7381719-B2 | Diaryl ethers as opioid receptor antagonist | ELI LILLY AND COMPANY (US) | 2008-06-03 | — | — | US | disclosed |
| US-20060217372-A1 | Diaryl ethers as opioid receptor antagonist | ELI LILLY AND COMPANY | 2006-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060217372-A1 | Diaryl ethers as opioid receptor antagonist | OPRM1, OPRL1, OPRD1 | KDM4E 608/4885ALDH1A1 2133/4885SMN1; SMN2 2558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.