Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.30 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12845562 | 0.77 | ALDH1A1 (0.34) | LMNAMAPTCYP2C9CYP2C19ESR2 | |
| SCHEMBL27716615 | 0.76 | TDP1 (0.45) | LMNAMAPTTDP1ALDH1A1 | |
| SCHEMBL27716582 | 0.76 | TSHR (0.45) | LMNAMAPTTDP1ALDH1A1 | |
| SCHEMBL3764475 | 0.68 | CA12 (0.42) | MAPTCYP2C9CYP2C19TDP1ALDH1A1 | |
| SCHEMBL5153906 | 0.68 | LMNA (0.33) | LMNAMAPTCYP2C9CYP2C19ESR2 | |
| SCHEMBL10494612 | 0.68 | KMT2A (0.54) | LMNAMAPTCYP2C9CYP2C19HSD17B10 | |
| SCHEMBL10494614 | 0.68 | KMT2A (0.54) | LMNAMAPTCYP2C9CYP2C19HSD17B10 | |
| SCHEMBL8990606 | 0.64 | LMNA (0.42) | LMNAMAPTCYP2C19ESR2HSD17B10 | |
| SCHEMBL11477824 | 0.64 | CES2 (0.35) | — | |
| SCHEMBL27576407 | 0.64 | PMM2 (0.41) | LMNAMAPTHSD17B10TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105348203-B | Inhibit the composition and method of JAK approach | 里格尔药品股份有限公司 | 2018-09-18 | — | — | CN | disclosed |
| CN-105348203-A | Compositions and methods for inhibition of the JAK pathway | RIGEL PHARMACEUTICALS INC | 2016-02-24 | — | — | CN | disclosed |
| CN-101282945-A | Compositions and methods for inhibiting the JAK pathway | RIGEL PHARMACEUTICALS INC (US) | 2008-10-08 | — | — | CN | disclosed |