Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.34 |
| ▸ | HTR3B | O95264 | 2/20 | 0.34 |
| ▸ | HTR3A | P46098 | 2/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11295534 | 0.77 | TSHR (0.50) | TSHRTP53CA12CA1CA2 | |
| SCHEMBL27716593 | 0.76 | LMNA (0.32) | TDP1MAPTLMNAALDH1A1 | |
| SCHEMBL27716615 | 0.76 | TDP1 (0.45) | TSHRTP53GAAMAPK1TDP1 | |
| SCHEMBL10889596 | 0.76 | GAA (0.42) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL11682158 | 0.76 | TSHR (0.46) | TSHRTP53CA12CA2CA9 | |
| SCHEMBL27716709 | 0.73 | ALDH1A1 (0.35) | GAAALDH1A1 | |
| SCHEMBL11684152 | 0.73 | TSHR (0.42) | TSHRTP53CA12CA1CA2 | |
| SCHEMBL11684625 | 0.73 | SENP3 (0.43) | TSHRTP53CA1CA2GAA | |
| SCHEMBL11647217 | 0.69 | MAPT (0.58) | TSHRTP53CA12CA1CA2 | |
| SCHEMBL11647216 | 0.69 | MAPT (0.58) | TSHRTP53CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105348203-B | Inhibit the composition and method of JAK approach | 里格尔药品股份有限公司 | 2018-09-18 | — | — | CN | disclosed |
| CN-105348203-A | Compositions and methods for inhibition of the JAK pathway | RIGEL PHARMACEUTICALS INC | 2016-02-24 | — | — | CN | disclosed |
| CN-101282945-A | Compositions and methods for inhibiting the JAK pathway | RIGEL PHARMACEUTICALS INC (US) | 2008-10-08 | — | — | CN | disclosed |