Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.57 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.53 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| M-Xylene SCHEMBL27720422 | 0.85 | BRAF (0.58) | CYP11B2CYP11B1GRM5CSF1RNAMPT | |
| SCHEMBL3941905 | 0.81 | CSF1R (0.77) | CYP11B2CYP11B1GRM5CSF1RKMT2A | |
| SCHEMBL27720628 | 0.78 | CSF1R (0.63) | CYP11B2CYP11B1CSF1RKMT2AMEN1 | |
| O-Xylene SCHEMBL27720472 | 0.78 | BRAF (0.62) | CYP11B2CSF1RKMT2AMEN1KDM4E | |
| SCHEMBL27699868 | 0.76 | CSF1R (0.70) | CYP11B2CSF1RKMT2AMEN1LMNA | |
| P-Xylene SCHEMBL28772414 | 0.76 | BRAF (0.65) | CYP11B2CSF1RNAMPT | |
| SCHEMBL3931994 | 0.75 | CSF1R (0.65) | CYP11B2CYP11B1GRM5CSF1RKMT2A | |
| SCHEMBL31171365 | 0.75 | CYP11B2 (0.71) | CYP11B2CYP11B1KMT2AMEN1NAMPT | |
| SCHEMBL3940427 | 0.74 | CYP11B2 (0.71) | CYP11B2CYP11B1SORT1GRM5CSF1R | |
| SCHEMBL4878207 | 0.74 | CYP11B2 (0.72) | CYP11B2CYP11B1SORT1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |