Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SLC26A4 | O43511 | 7/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2083018 | 0.89 | SMN1; SMN2 (0.49) | HSD11B1ALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL4965650 | 0.80 | KDM4E (0.64) | ALDH1A1SMN1; SMN2SLC26A4KDM4EHPGD | |
| SCHEMBL28500191 | 0.78 | HSD11B1 (0.61) | HSD11B1ALDH1A1KDM4EHPGDSTS | |
| SCHEMBL1697068 | 0.77 | HSD11B1 (0.45) | HSD11B1ALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL10847170 | 0.77 | HPGD (0.72) | HSD11B1HPGDSTSMAOB | |
| SCHEMBL16655989 | 0.77 | SLC26A4 (0.55) | ALDH1A1SMN1; SMN2HTTLMNASLC26A4 | |
| SCHEMBL31604843 | 0.77 | PTGS2 (0.66) | ALDH1A1SMN1; SMN2HTTLMNAKDM4E | |
| SCHEMBL13155387 | 0.77 | HSD11B1 (0.48) | HSD11B1ALDH1A1KDM4EHPGDPOLB | |
| SCHEMBL30301334 | 0.76 | HSD11B1 (0.51) | HSD11B1ALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL1938706 | 0.76 | HSD11B1 (0.51) | HSD11B1ALDH1A1SMN1; SMN2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |