Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL27703064 | 0.88 | DRD2 (0.53) | HTR1AHTR7GPR52DRD2PARP1 | |
| SCHEMBL4760717 | 0.87 | HTR1A (0.44) | HTR1AHTR7GPR52KDM1ACHRM2 | |
| SCHEMBL4625851 | 0.81 | HTR1A (0.47) | HTR1AHTR7PARP1PRKAB2PRKAG1 | |
| SCHEMBL4220301 | 0.80 | PRKAB2 (0.63) | HTR1AHTR7GPR52DRD2KDM1A | |
| SCHEMBL4597052 | 0.77 | HTR1A (0.39) | HTR1AHTR7GPR52PARP1CHRM3 | |
| SCHEMBL4712620 | 0.77 | MAOA (0.38) | HTR1AHTR7PARP1MAOAMAOB | |
| Ammonia Solution, Strong SCHEMBL27703077 | 0.77 | PARP1 (0.43) | HTR1ADRD2PARP1MAOAMAOB | |
| SCHEMBL4220355 | 0.77 | HTR1A (0.48) | HTR1AHTR7GPR52DRD2PRKAB2 | |
| SCHEMBL4595448 | 0.76 | HTR1A (0.39) | HTR1AHTR7PARP1CHRM3MAOA | |
| SCHEMBL4597055 | 0.76 | HTR1A (0.49) | HTR1AHTR7DRD2PARP1PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101448492-A | Methods of treating cognitive and other disorders | WYETH CORP (US) | 2009-06-03 | — | — | CN | claimed |
| CN-101389325-A | Treatment of drug abuse | WYETH CORP (US) | 2009-03-18 | — | — | CN | claimed |
| CN-101203217-A | Methods for modulating bladder function | WYETH CORP (US) | 2008-06-18 | — | — | CN | claimed |
| CN-101198322-A | Novel therapeutic combinations for the treatment or prevention of depression | WYETH CORP (US) | 2008-06-11 | — | — | CN | claimed |
| CN-101198323-A | Therapeutic combinations for the treatment or prevention of psychotic disorders | WYETH CORP (US) | 2008-06-11 | — | — | CN | claimed |
| CN-101189004-A | Treatment of pain | WYETH CORP (US) | 2008-05-28 | — | — | CN | claimed |
| CN-101448492-A | Methods of treating cognitive and other disorders | WYETH CORP (US) | 2009-06-03 | — | — | CN | disclosed |
| CN-101389325-A | Treatment of drug abuse | WYETH CORP (US) | 2009-03-18 | — | — | CN | disclosed |
| CN-101203217-A | Methods for modulating bladder function | WYETH CORP (US) | 2008-06-18 | — | — | CN | disclosed |
| CN-101203216-A | Dihydrobenzofuran derivatives and uses thereof | WYETH CORP (US) | 2008-06-18 | — | — | CN | disclosed |
| CN-101198322-A | Novel therapeutic combinations for the treatment or prevention of depression | WYETH CORP (US) | 2008-06-11 | — | — | CN | disclosed |
| CN-101198323-A | Therapeutic combinations for the treatment or prevention of psychotic disorders | WYETH CORP (US) | 2008-06-11 | — | — | CN | disclosed |
| CN-101189004-A | Treatment of pain | WYETH CORP (US) | 2008-05-28 | — | — | CN | disclosed |