SCHEMBL27728679

SCHEMBL27728679

C=Cc1ccccc1-c1ccc(CCl)cc1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.41
MAOB P27338 2/20 0.36
AKT1 P31749 1/20 0.32
FLT3 P36888 2/20 0.31
XDH P47989 1/20 0.31
GRIN2D O15399 2/20 0.31
GRIN3B O60391 2/20 0.31
GRIN1 Q05586 2/20 0.31
GRIN2A Q12879 2/20 0.31
GRIN2B Q13224 2/20 0.31
GRIN2C Q14957 2/20 0.31
GRIN3A Q8TCU5 2/20 0.31
POLB P06746 1/20 0.31
PTGER1 P34995 1/20 0.30
PTGER3 P43115 1/20 0.30
PTGER2 P43116 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2467050 0.84 ALDH1A1 (0.48) ALDH1A1FLT3XDHGRIN2DGRIN3B
SCHEMBL4508207 0.81 TP53 (0.41) ALDH1A1
SCHEMBL19089877 0.80 ALDH1A1 (0.39) ALDH1A1
SCHEMBL10896799 0.80 MAOB (0.45) MAOBAKT1
SCHEMBL5132867 0.79 THRB (0.41) ALDH1A1MAOB
SCHEMBL7760471 0.79 ALDH1A1 (0.50) ALDH1A1PTGER1PTGER3PTGER2
SCHEMBL8758641 0.78 ALDH1A1 (0.43) ALDH1A1FLT3GRIN2DGRIN3BGRIN1
SCHEMBL76904 0.78 ALDH1A1 (0.46) ALDH1A1FLT3GRIN2DGRIN3BGRIN1
SCHEMBL29418124 0.78 ALDH1A1 (0.46) ALDH1A1FLT3GRIN2DGRIN3BGRIN1
SCHEMBL7804618 0.77 S1PR1 (0.40) POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101346338-A Dicarboxylic acid derivatives and their use BAYER HEALTHCARE AG (DE) 2009-01-14 CN disclosed