Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.34 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28770717 | 0.83 | KDM4E (0.35) | NOTUMKDM4EALDH1A1DRD4DRD3 | |
| SCHEMBL27732197 | 0.83 | TSHR (0.38) | DRD2DRD4DRD3 | |
| SCHEMBL27732182 | 0.80 | KMT2A (0.37) | ALDH1A1DRD4 | |
| SCHEMBL29018640 | 0.80 | PRKCZ (0.38) | PRKCZNOTUMADRB1KDM4EALDH1A1 | |
| SCHEMBL27732200 | 0.80 | HCAR1 (0.42) | HCAR1 | |
| SCHEMBL28774867 | 0.80 | MEN1 (0.36) | PRKCZKDM4EALDH1A1 | |
| SCHEMBL27712132 | 0.79 | DRD2 (0.40) | ADRA1DADRA1AADRA1BALDH1A1DRD2 | |
| SCHEMBL27732180 | 0.78 | GAA (0.39) | ADRB1KDM4EALDH1A1RAB9A | |
| SCHEMBL27732185 | 0.77 | PRKCZ (0.42) | PRKCZKDM4E | |
| SCHEMBL27712215 | 0.76 | KMT2A (0.35) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101243050-B | Pyrazolone derivatives | HOFFMANN LA ROCHE | 2012-07-04 | — | — | CN | disclosed |
| CN-101243050-A | Pyrazolone derivatives | HOFFMANN LA ROCHE (CH) | 2008-08-13 | — | — | CN | disclosed |