Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9058909 | 0.89 | GABRA1 (0.43) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| SCHEMBL27702860 | 0.85 | PDK2 (0.41) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| SCHEMBL10970621 | 0.85 | HSP90AB1 (0.44) | KDM4EHIF1ATDP1HSP90AB1PDK2 | |
| SCHEMBL27420704 | 0.83 | L3MBTL1 (0.41) | HMGB1KDM4EHSP90AB1PDK2 | |
| SCHEMBL27753882 | 0.82 | GABRA1 (0.41) | LMNAHMGB1KDM4EHSP90AB1GABRA1 | |
| SCHEMBL27753896 | 0.82 | PNMT (0.47) | LMNAHMGB1HSP90AB1GABRA1GABRB2 | |
| SCHEMBL27835898 | 0.82 | HMGB1 (0.49) | HMGB1KDM4EHSP90AB1GABRA1GABRB2 | |
| SCHEMBL27709094 | 0.81 | HMGB1 (0.37) | LMNAHMGB1HSP90AB1GABRA1GABRB2 | |
| SCHEMBL27499175 | 0.81 | GABRA1 (0.44) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| SCHEMBL5965437 | 0.79 | G6PD (0.57) | ABCB11LMNAPTGS1ADORA1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101370786-B | Substituted imidazoles and their use as pesticides | PFIZER | 2012-01-11 | — | — | CN | disclosed |
| CN-101370786-A | Substituted imidazoles and their use as pesticides | PFIZER LTD (GB) | 2009-02-18 | — | — | CN | disclosed |