SCHEMBL27735339

SCHEMBL27735339

Nc1ccc(-c2ncco2)s1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2E1 P05181 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2A6 P11509 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2B6 P20813 1/20 0.42
CYP2C19 P33261 1/20 0.42
LTA4H P09960 2/20 0.39
ADORA2A P29274 3/20 0.36
ADORA1 P30542 3/20 0.36
HPGDS O60760 1/20 0.36
PIN1 Q13526 1/20 0.31
BACE1 P56817 2/20 0.31
BACE2 Q9Y5Z0 2/20 0.31
BRD4 O60885 1/20 0.31
HPGD P15428 1/20 0.31
SCD O00767 1/20 0.30
CSNK1A1 P48729 1/20 0.30
CSNK1D P48730 1/20 0.30
CSNK1E P49674 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5030066 0.77 LTA4H (0.39) LTA4HADORA2AADORA1HPGDSBRD4
SCHEMBL5270393 0.76 IL2 (0.40) CYP2E1CYP3A4CYP2D6CYP2A6CYP2C9
SCHEMBL5271643 0.76 IL2 (0.54) CYP2E1CYP3A4CYP2D6CYP2A6CYP2C9
SCHEMBL22188117 0.74 PTGS2 (0.38) CYP2E1CYP3A4CYP2D6CYP2A6CYP2C9
SCHEMBL24243094 0.73 LTA4H (0.39) CYP2C9CYP2C19LTA4HADORA2AADORA1
SCHEMBL6259248 0.72 KDM4E (0.53) HPGDSHPGD
SCHEMBL3462241 0.70 USP9X (0.38) LTA4HHPGDSBRD4
SCHEMBL20016442 0.69 NOTUM (0.42) CYP2E1CYP3A4CYP2D6CYP2A6CYP2C9
SCHEMBL9912150 0.68 CYP2E1 (0.50) CYP2E1CYP3A4CYP2D6CYP2A6CYP2C9
SCHEMBL100765 0.68 HPGDS (0.46) LTA4HADORA2AADORA1HPGDSPIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101316853-B Benzothiazole and thiazolopyridine as SIRTUIN modulators SIRTRIS PHARMACEUTICALS INC 2014-09-24 CN disclosed
CN-103145738-A Imidazo [2,1-b] thiayole derivatives as SIRTUIN modulating compounds SIRTRIS PHARMACEUTICALS INC 2013-06-12 CN disclosed
CN-101316853-A Benzothiazole and thiazolopyridine as SIRTUIN modulators SIRTRIS PHARMACEUTICALS INC (US) 2008-12-03 CN disclosed
CN-101282761-A Benzimidazole derivatives as SIRTUIN modulators SIRTRIS PHARMACEUTICALS INC (US) 2008-10-08 CN disclosed
CN-101282974-A Benzimidazole derivatives as SIRTUIN modulators SIRTRIS PHARMACEUTICALS INC (US) 2008-10-08 CN disclosed
CN-101277963-A Benzimidazole derivatives as SIRTUIN modulators SIRTIS PHARMACEUTICALS INC (US) 2008-10-01 CN disclosed
CN-101277965-A Imidazo [2, 1-b ] thiazole derivatives as SIRTUIN modulating compounds SIRTRIS PHARMACEUTICALS INC (US) 2008-10-01 CN disclosed