Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | NOS3 | P29474 | 2/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | MPI | P34949 | 1/20 | 0.30 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326929 | 0.84 | NOS2 (0.48) | NOS2KDM4ENOS3ALDH1A1NOS1 | |
| SCHEMBL5930653 | 0.82 | SMN1; SMN2 (0.36) | NOS2KDM4ENOS3ALDH1A1NOS1 | |
| SCHEMBL5673102 | 0.82 | NOTUM (0.33) | MYCNOS2KDM4ENOS3CCR1 | |
| SCHEMBL8328137 | 0.81 | NOS2 (0.51) | NOS2KDM4ENOS3ALDH1A1NOS1 | |
| SCHEMBL2776731 | 0.81 | KDM4E (0.33) | NOS2KDM4ENOS3ALDH1A1NOS1 | |
| SCHEMBL13040603 | 0.80 | NOS2 (0.39) | NOS2NOS3NOS1 | |
| SCHEMBL16018333 | 0.80 | NOS3 (0.36) | MYCNOS2NOS3NOS1 | |
| SCHEMBL2834751 | 0.79 | NOS1 (0.44) | NOS2NOS3NOS1 | |
| SCHEMBL8329772 | 0.79 | NOS2 (0.39) | NOS2NOS3NOS1 | |
| SCHEMBL5672155 | 0.79 | NOS2 (0.36) | NOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10167260-B2 | 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2019-01-01 | — | — | US | disclosed |
| US-9951014-B2 | Mammalian and bacterial nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2018-04-24 | — | — | US | disclosed |
| US-20170298021-A1 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-10-19 | — | — | US | disclosed |
| US-20170298021-A1 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-10-19 | — | — | US | disclosed |
| US-20170275278-A1 | Mammalian and Bacterial Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-09-28 | — | — | US | disclosed |
| US-20170275278-A1 | Mammalian and Bacterial Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-09-28 | — | — | US | disclosed |
| US-9732037-B2 | 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-08-15 | — | — | US | disclosed |
| US-9732037-B2 | 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-08-15 | — | — | US | disclosed |
| US-20160347713-A1 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY | 2016-12-01 | — | — | US | disclosed |
| US-20160347713-A1 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY | 2016-12-01 | — | — | US | disclosed |
| US-8829187-B1 | Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase | NORTHWESTERN UNIVERSITY (US) | 2014-09-09 | — | — | US | disclosed |
| US-8829187-B1 | Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase | NORTHWESTERN UNIVERSITY (US) | 2014-09-09 | — | — | US | disclosed |
| US-8389731-B2 | Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase | NORTHWESTERN UNIVERSITY (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389731-B2 | Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase | NORTHWESTERN UNIVERSITY (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389731-B2 | Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase | NORTHWESTERN UNIVERSITY (US) | 2013-03-05 | — | — | US | disclosed |
| US-20100292484-A1 | Chiral Pyrrolidine Core Compounds en route to Inhibitors of Nitric Oxide Synthase | NORTHESTERN UNIVERSITY | 2010-11-18 | — | — | US | disclosed |
| US-20100292484-A1 | Chiral Pyrrolidine Core Compounds en route to Inhibitors of Nitric Oxide Synthase | NORTHESTERN UNIVERSITY | 2010-11-18 | — | — | US | disclosed |
| US-20100292484-A1 | Chiral Pyrrolidine Core Compounds en route to Inhibitors of Nitric Oxide Synthase | NORTHESTERN UNIVERSITY | 2010-11-18 | — | — | US | disclosed |
| WO-2010132873-A2 | CHIRAL PYRROLIDINE CORE COMPOUNDS EN ROUTE TO INHIBITORS OF NITRIC OXIDE SYNTHASE | NORTHWESTERN UNIVERSITY (US) | 2010-11-18 | — | — | WO | disclosed |
| WO-2010132873-A2 | CHIRAL PYRROLIDINE CORE COMPOUNDS EN ROUTE TO INHIBITORS OF NITRIC OXIDE SYNTHASE | NORTHWESTERN UNIVERSITY (US) | 2010-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160347713-A1 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors | NOS2, NOS1, NOS3 | MYC 4442/4885NOS2 1/4885KDM4E 1514/4885 |
| US-20170275278-A1 | Mammalian and Bacterial Nitric Oxide Synthase Inhibitors | NOS1, NOS2, NOS3 | MYC 2236/4885NOS2 2/4885KDM4E 3861/4885 |
| US-10167260-B2 | 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors | NOS2, NOS1, NOS3 | MYC 4442/4885NOS2 1/4885KDM4E 1514/4885 |
| US-20100292484-A1 | Chiral Pyrrolidine Core Compounds en route to Inhibitors of Nitric Oxide Synthase | NOS1, NOS2, NOS3 | MYC 3079/4885NOS2 2/4885KDM4E 2137/4885 |
| US-20170298021-A1 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors | NOS2, NOS1, NOS3 | MYC 4442/4885NOS2 1/4885KDM4E 1514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.