Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MYC | P01106 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 3/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5672155 | 0.86 | NOS2 (0.36) | NOS2NOS3NOS1 | |
| SCHEMBL8326929 | 0.84 | NOS2 (0.48) | GRIN2DGRIN3BCHRM1ADRA1DADRA1A | |
| SCHEMBL6164525 | 0.82 | NOS2 (0.39) | NOS2NOS3NOS1 | |
| SCHEMBL2773550 | 0.82 | MYC (0.32) | MYCNOS2NOS3CCR1KDM4E | |
| SCHEMBL5930653 | 0.82 | SMN1; SMN2 (0.36) | NOS2NOS3KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL13040592 | 0.81 | NOS2 (0.54) | NOS2NOS3KDM4ENOS1 | |
| SCHEMBL6167004 | 0.81 | NOS2 (0.38) | NOS2NOS3NOS1 | |
| SCHEMBL13040655 | 0.81 | NOS2 (0.38) | NOS2NOS3NOS1 | |
| SCHEMBL8328137 | 0.81 | NOS2 (0.51) | MAPTNOS2NOS3KDM4EALDH1A1 | |
| SCHEMBL2776731 | 0.81 | KDM4E (0.33) | MAPTNOS2NOS3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060194847-A1 | Novel 6-substituted 2-aminopyridine derivatives | ASTRAZENECA AB (SE) | 2006-08-31 | — | — | US | disclosed |
| EP-1611099-A1 | NOVEL 6-SUBSTITUTED 2-AMINOPYRIDINE DERIVATIVES | AstraZeneca AB (SE) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004087665-A1 | NOVEL 6-SUBSTITUTED 2-AMINOPYRIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194847-A1 | Novel 6-substituted 2-aminopyridine derivatives | NOS1, NOS2, NOS3 | NOTUM 2877/4885S1PR2 2417/4885GRIN2D 255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.