Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | PTGES | O14684 | 5/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13064477 | 0.89 | POLB (0.65) | POLBL3MBTL1TP53PTGESALOX5 | |
| SCHEMBL2774660 | 0.85 | PTGES (0.65) | PTGESALOX5KMT2ANR1I2KDM4E | |
| SCHEMBL13064400 | 0.83 | POLB (0.59) | POLBTP53PTGESALOX5KMT2A | |
| SCHEMBL2776393 | 0.83 | TP53 (0.72) | POLBTP53PTGESALOX5KMT2A | |
| SCHEMBL25412633 | 0.76 | ALDH1A1 (0.63) | POLBL3MBTL1TP53KMT2ANR1I2 | |
| SCHEMBL3275261 | 0.74 | PTGES (0.59) | L3MBTL1PTGESALOX5NR1I2RAB9A | |
| SCHEMBL3641266 | 0.73 | GRM2 (0.65) | PTGESALOX5NR1I2RAB9AGRM2 | |
| SCHEMBL13065008 | 0.72 | TP53 (0.62) | POLBL3MBTL1TP53KMT2ACNR1 | |
| SCHEMBL16587180 | 0.72 | TRPM8 (0.77) | — | |
| SCHEMBL3278663 | 0.72 | PTGES (0.84) | PTGESALOX5KMT2ANR1I2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130638-A1 | SULFONAMIDE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | EVOTEC AG (DE) | 2010-11-18 | — | — | WO | disclosed |