Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | PTGES | O14684 | 6/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | CNR1 | P21554 | 1/20 | 0.57 |
| ▸ | CNR2 | P34972 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2776393 | 0.92 | TP53 (0.72) | POLBTP53PTGESALOX5NR3C1 | |
| SCHEMBL13064400 | 0.92 | POLB (0.59) | POLBTP53PTGESALOX5NR3C1 | |
| SCHEMBL2773872 | 0.89 | POLB (0.53) | POLBTP53PTGESALOX5NR3C1 | |
| SCHEMBL3275261 | 0.84 | PTGES (0.59) | PTGESALOX5NR3C1NR1I2L3MBTL1 | |
| SCHEMBL3278663 | 0.83 | PTGES (0.84) | PTGESALOX5NR3C1NR1I2KMT2A | |
| SCHEMBL25412633 | 0.82 | ALDH1A1 (0.63) | POLBTP53NR1I2KMT2AL3MBTL1 | |
| SCHEMBL13065008 | 0.80 | TP53 (0.62) | POLBTP53KMT2ACNR1CNR2 | |
| SCHEMBL1169287 | 0.80 | LMNA (0.73) | PTGESALOX5NR3C1KMT2ACNR1 | |
| SCHEMBL13064474 | 0.78 | KMT2A (0.63) | POLBKMT2AALDH1A1LMNANPSR1 | |
| SCHEMBL5330652 | 0.78 | ESR1 (0.78) | PTGESALOX5NR3C1NR1I2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130638-A1 | SULFONAMIDE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | EVOTEC AG (DE) | 2010-11-18 | — | — | WO | disclosed |