Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | MST1R | Q04912 | 1/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27720111 | 0.90 | KDR (0.49) | RAB9ANPC1MAPK14FGFR1FGFR2 | |
| SCHEMBL27720139 | 0.88 | ALDH1A1 (0.52) | RAB9ANPC1MAPK14FGFR1FGFR2 | |
| SCHEMBL27720155 | 0.82 | BRAF (0.64) | RAB9ANPC1MAPK14KDRMAPT | |
| SCHEMBL27720117 | 0.81 | BRAF (0.61) | RAB9ANPC1KMT2AMAPTTSHR | |
| SCHEMBL27720100 | 0.81 | BRAF (0.63) | RAB9ANPC1MAPK14FGFR1FGFR2 | |
| SCHEMBL27740980 | 0.81 | MAPK14 (0.56) | MAPK14KDRABL1METSRC | |
| SCHEMBL27720255 | 0.79 | RAB9A (0.58) | RAB9ANPC1KMT2AMAPTTSHR | |
| SCHEMBL27720157 | 0.78 | MAPT (0.64) | RAB9ANPC1MAPK14FGFR1FGFR2 | |
| SCHEMBL27720178 | 0.78 | RAB9A (0.60) | RAB9ANPC1KDRKMT2AMAPT | |
| SCHEMBL27740983 | 0.78 | CDK8 (0.56) | RAB9ANPC1MAPK14KDRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101298427-B | Diaryl urea compound and use thereof | GUANGZHOU INST BIOMED & HEALTH | 2012-03-21 | — | — | CN | disclosed |
| CN-101298427-A | Diaryl urea compound and use thereof | GUANGZHOU INST BIOMED & HEALTH (CN) | 2008-11-05 | — | — | CN | disclosed |