Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 5/20 | 0.51 |
| ▸ | HTR2C | P28335 | 4/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 4/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27720161 | 0.96 | HTR2A (0.51) | MAPK14HTR2AHTR2CMCHR1MET | |
| SCHEMBL27741147 | 0.92 | EPHX2 (0.56) | MAPK14HTR2AHTR2CMETKDR | |
| SCHEMBL27740985 | 0.88 | EPHX2 (0.62) | MAPK14HTR2AHTR2CEGFRKDR | |
| SCHEMBL27740980 | 0.84 | MAPK14 (0.56) | MAPK14METSRCKDREPHX2 | |
| SCHEMBL27720139 | 0.84 | ALDH1A1 (0.52) | MAPK14HTR2AHTR2CMETSRC | |
| SCHEMBL27740978 | 0.80 | PNLIP (0.51) | MAPK14HTR2AHTR2CMETSRC | |
| SCHEMBL27720113 | 0.80 | BRAF (0.48) | MAPK14HTR2AHTR2CMETSRC | |
| SCHEMBL27720157 | 0.80 | MAPT (0.64) | MAPK14HTR2AHTR2CMETSRC | |
| SCHEMBL27740975 | 0.79 | RAB9A (0.50) | MAPK14METSRCKDREPHX2 | |
| SCHEMBL27720100 | 0.77 | BRAF (0.63) | MAPK14HTR2AHTR2CMETSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101298427-B | Diaryl urea compound and use thereof | GUANGZHOU INST BIOMED & HEALTH | 2012-03-21 | — | — | CN | disclosed |
| CN-101298427-A | Diaryl urea compound and use thereof | GUANGZHOU INST BIOMED & HEALTH (CN) | 2008-11-05 | — | — | CN | disclosed |