Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PTGIR | P43119 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6230454 | 0.77 | KMT2A (0.45) | KMT2ATRPM8L3MBTL1LMNAPOLB | |
| SCHEMBL14300714 | 0.76 | PTGIR (0.55) | KMT2ATRPM8L3MBTL1RAB9ANPC1 | |
| SCHEMBL6180145 | 0.75 | KMT2A (0.54) | KMT2ATRPM8L3MBTL1RAB9ANPC1 | |
| SCHEMBL2787089 | 0.75 | L3MBTL1 (0.47) | KMT2ATRPM8L3MBTL1RAB9ANPC1 | |
| SCHEMBL6226157 | 0.74 | RPS6KA3 (0.46) | KMT2AL3MBTL1KDM4ELMNAPOLB | |
| SCHEMBL28139404 | 0.74 | ALDH1A1 (0.48) | KMT2ARAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL27768259 | 0.74 | L3MBTL1 (0.42) | KMT2AL3MBTL1RAB9ANPC1PTGIR | |
| SCHEMBL6225886 | 0.73 | TLR7 (0.44) | KMT2AL3MBTL1RAB9ASMN1; SMN2GAA | |
| SCHEMBL1978108 | 0.73 | CES2 (0.47) | RAB9ANPC1PTGS1KDM4EALDH1A1 | |
| SCHEMBL16343437 | 0.71 | CYP1A2 (0.44) | PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466710-B | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC | 2013-05-29 | — | — | CN | disclosed |
| CN-101466710-A | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2009-06-24 | — | — | CN | disclosed |