Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | PTGIR | P43119 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28139404 | 0.78 | ALDH1A1 (0.48) | SMN1; SMN2MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL27747166 | 0.74 | KMT2A (0.51) | L3MBTL1SMN1; SMN2ALDH1A1KMT2APTGIR | |
| SCHEMBL27745477 | 0.73 | MAPT (0.45) | L3MBTL1SMN1; SMN2ALDH1A1MAPTNPSR1 | |
| SCHEMBL28487270 | 0.73 | ADRA2A (0.41) | L3MBTL1PTK2MAOBSMN1; SMN2MEN1 | |
| SCHEMBL525912 | 0.73 | ADRA2A (0.41) | L3MBTL1PTK2MAOBSMN1; SMN2MEN1 | |
| SCHEMBL28028214 | 0.72 | ADRA2A (0.35) | L3MBTL1PTK2MAOBSMN1; SMN2MEN1 | |
| SCHEMBL11845573 | 0.71 | HCAR3 (0.48) | L3MBTL1PTK2SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL19102454 | 0.71 | ADRA2A (0.41) | L3MBTL1PTK2MAOBSMN1; SMN2MEN1 | |
| SCHEMBL27619934 | 0.70 | PTK2 (0.47) | L3MBTL1PTK2MAOBSMN1; SMN2MEN1 | |
| SCHEMBL3953896 | 0.70 | ALOX15 (0.44) | L3MBTL1SMN1; SMN2MEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108289893-A | Human plasma kallikrein inhibitors | 拜奥克里斯特制药公司 | 2018-07-17 | — | — | CN | disclosed |
| CN-101466710-B | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC | 2013-05-29 | — | — | CN | disclosed |
| CN-101821279-A | Certain chemical entities, compositions, and methods | CYTOKINETICS INC | 2010-09-01 | — | — | CN | disclosed |
| CN-101466710-A | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2009-06-24 | — | — | CN | disclosed |