Sugi Predict

Sugi Predict / Compounds / SCHEMBL2787089

SCHEMBL2787089

SCHEMBL2787089

CN(N)c1ccc(C(F)(F)F)cn1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 2/20 0.47
▸ KMT2A Q03164 2/20 0.44
▸ JAK2 O60674 1/20 0.40
▸ JAK1 P23458 1/20 0.40
▸ GAA P10253 4/20 0.40
▸ SMN1; SMN2 Q16637 3/20 0.38
▸ KDM4E B2RXH2 3/20 0.38
▸ NPSR1 Q6W5P4 2/20 0.38
▸ LMNA P02545 1/20 0.38
▸ HTT P42858 1/20 0.38
▸ TSHR P16473 1/20 0.37
▸ PTGS1 P23219 1/20 0.36
▸ NPC1 O15118 1/20 0.36
▸ RAB9A P51151 1/20 0.36
▸ HPGD P15428 1/20 0.36
▸ TRPM8 Q7Z2W7 1/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ APAF1 O14727 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ TDP1 Q9NUW8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14180516 0.84 L3MBTL1 (0.46) L3MBTL1KMT2AJAK2JAK1GAA
SCHEMBL8979076 0.78 L3MBTL1 (0.48) L3MBTL1KMT2AJAK2JAK1GAA
SCHEMBL14554355 0.78 L3MBTL1 (0.48) L3MBTL1KMT2AJAK2JAK1GAA
SCHEMBL24527457 0.77 L3MBTL1 (0.41) L3MBTL1KMT2AJAK2JAK1GAA
SCHEMBL22452597 0.76 PTGS1 (0.43) L3MBTL1KMT2AJAK2JAK1GAA
SCHEMBL13417452 0.76 GBA1 (0.55) L3MBTL1KMT2AGAASMN1; SMN2KDM4E
SCHEMBL27747166 0.75 KMT2A (0.51) L3MBTL1KMT2AGAASMN1; SMN2KDM4E
SCHEMBL14438103 0.74 L3MBTL1 (0.40) L3MBTL1KMT2AJAK2JAK1GAA
SCHEMBL14547837 0.74 TDO2 (0.36) KMT2AJAK2JAK1GAA
SCHEMBL3216629 0.72 NOS3 (0.53) L3MBTL1GAANPSR1TSHRNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101646656-B Pyrimidine hydrazide compounds as PGDS inhibitors SANOFI AVENTIS SPA 2013-08-14 — — CN claimed
CN-101646656-A Pyrimidine hydrazide compounds as the PGDS inhibitor SANOFI AVENTIS FR 2010-02-10 — — CN claimed
EP-2376487-B1 THIAZOLYL OXIME ETHER AND HYDRAZONES AS PLANT PROTECTION AGENT BAYER IP GMBH (DE) 2016-01-06 — — EP disclosed
US-9215875-B2 Thiazolyl oxime ethers and hydrazones as crop protection agents BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-12-22 — — US disclosed
US-20140296289-A1 Thiazolyl Oxime Ethers and Hydrazones as Crop Protection Agents BAYER CROPSCIENCE AG (DE) 2014-10-02 — — US disclosed
US-8697878-B2 Thiazolyl oxime ethers and hydrazones as crop protection agents BAYER CROPSCIENCE AG (DE) 2014-04-15 — — US disclosed
CN-101646656-B Pyrimidine hydrazide compounds as PGDS inhibitors SANOFI AVENTIS SPA 2013-08-14 — — CN disclosed
US-8258130-B2 Pyrimidine hydrazide compounds as PGDS inhibitors SANOFI (FR) 2012-09-04 — — US disclosed
CN-102292334-A Thiazolyl oxime ether and hydrazones asl plant protection agent — 2011-12-21 — — CN disclosed
US-20100190828-A1 Thiazolyl oxime ethers and hydrazones as crop protection agents BAYER CROPSCIENCE AG (DE) 2010-07-29 — — US disclosed
US-20100048568-A1 PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS SANOFI-AVENTIS (FR) 2010-02-25 — — US disclosed
US-6887863-B2 Hydrazide and alkoxyamide angiogenesis inhibitors ABBOTT LABORATORIES (US) 2005-05-03 — — US disclosed
EP-1272456-B1 HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS ABBOTT LAB (US) 2004-10-27 — — EP disclosed
US-20040167126-A1 Hydrazide and alkoxyamide angiogenesis inhibitors ABBVIE INC. 2004-08-26 — — US disclosed
EP-1272456-A1 HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS Abbott Laboratories (US) 2003-01-08 — — EP disclosed
US-20020002152-A1 Hydrazide and alkoxyamide angiogenesis inhibitors ABBOTT LABORATORIES 2002-01-03 — — US disclosed
WO-2001079157-A1 HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS ABBOTT LABORATORIES (US) 2001-10-25 — — WO disclosed
US-5833885-A LENSES, ULTRAVIOLET RADIATION PROTECTION PILKINGTON PLC (GB) 1998-11-10 — — US disclosed
EP-0713491-A1 SPIRO(INDOLINO) OXAZINE PHOTOCHROMIC COMPOUNDS PILKINGTON PLC (GB) 1996-05-29 — — EP disclosed
WO-1995005385-A1 SPIRO(INDOLINO) OXAZINE PHOTOCHROMIC COMPOUNDS PILKINGTON PLC (GB) 1995-02-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140296289-A1 Thiazolyl Oxime Ethers and Hydrazones as Crop Protection Agents OXSR1, FOXO1, HAX1 L3MBTL1 119/4885KMT2A 780/4885JAK2 304/4885
US-20100190828-A1 Thiazolyl oxime ethers and hydrazones as crop protection agents OXSR1, FOXO1, HAX1 L3MBTL1 119/4885KMT2A 780/4885JAK2 304/4885
US-20040167126-A1 Hydrazide and alkoxyamide angiogenesis inhibitors METAP2, METAP1, ANPEP L3MBTL1 2554/4885KMT2A 648/4885JAK2 3087/4885
US-20100048568-A1 PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS HRH2, HRH1, HRH4 L3MBTL1 3418/4885KMT2A 3378/4885JAK2 1345/4885
US-20020002152-A1 Hydrazide and alkoxyamide angiogenesis inhibitors METAP2, METAP1, ANPEP L3MBTL1 2554/4885KMT2A 648/4885JAK2 3087/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.