Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.49 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.49 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27748883 | 0.89 | ACHE (0.68) | HPGDGAALMNAL3MBTL3ACHE | |
| SCHEMBL10196662 | 0.87 | KMT2A (0.65) | HPGDGAALMNAL3MBTL3POLB | |
| SCHEMBL31003116 | 0.87 | HSD11B1 (0.57) | HPGDGAALMNAL3MBTL3ACHE | |
| SCHEMBL19915895 | 0.86 | MGLL (0.56) | HPGDGAALMNAL3MBTL3ACHE | |
| SCHEMBL95384 | 0.86 | HPGD (0.52) | HPGDGAALMNAL3MBTL3ACHE | |
| SCHEMBL28355937 | 0.86 | EPHX1 (0.54) | HPGDGAALMNAL3MBTL3POLB | |
| SCHEMBL25442209 | 0.83 | KMT2A (0.63) | HPGDGAALMNAL3MBTL3POLB | |
| SCHEMBL15317691 | 0.83 | MEN1 (0.63) | HPGDLMNAPOLBKMT2AMEN1 | |
| SCHEMBL20645608 | 0.83 | HPGD (0.50) | HPGDGAALMNAL3MBTL3ACHE | |
| SCHEMBL744630 | 0.83 | LMNA (0.49) | HPGDGAALMNAL3MBTL3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110759889-B | 2-aryl amido substituted thiophene imide ester compound and preparation method and application thereof | 中国医学科学院药物研究所 | 2022-05-20 | — | — | CN | disclosed |
| CN-110759889-A | 2-aryl amido substituted thiophene imide ester compound and preparation method and application thereof | 中国医学科学院药物研究所 | 2020-02-07 | — | — | CN | disclosed |