Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL60410 | 0.82 | ALDH1A1 (0.42) | SOAT1ALDH1A1NPSR1GLO1LMNA | |
| SCHEMBL15059134 | 0.80 | MAPT (0.40) | SOAT1ALDH1A1ALOX15GAAMAPT | |
| SCHEMBL14134298 | 0.80 | ALDH1A1 (0.44) | SOAT1ALDH1A1NPSR1GLO1LMNA | |
| SCHEMBL28035204 | 0.80 | ALDH1A1 (0.32) | ALDH1A1TSHREGLN1 | |
| SCHEMBL1148993 | 0.79 | SOAT1 (0.46) | SOAT1ALDH1A1LMNAHSD17B10ALOX15 | |
| SCHEMBL5752815 | 0.77 | SOAT1 (0.39) | SOAT1ALDH1A1NPSR1GLO1LMNA | |
| SCHEMBL166879 | 0.77 | ALDH1A1 (0.46) | SOAT1ALDH1A1NPSR1GLO1LMNA | |
| SCHEMBL2779427 | 0.76 | ALOX15 (0.35) | SOAT1ALDH1A1NPSR1GLO1LMNA | |
| SCHEMBL2779431 | 0.76 | ALOX15 (0.35) | SOAT1ALDH1A1NPSR1GLO1LMNA | |
| SCHEMBL3999724 | 0.75 | MMP8 (0.36) | SOAT1ALDH1A1NPSR1GLO1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3317252-B1 | A GENERAL PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED OR 5,6-DISUBSTITUTED DERIVATIVES OF 2-AMINO-ISONICOTINIC ACID | BOEHRINGER INGELHEIM INT (DE) | 2019-05-22 | — | — | EP | disclosed |
| US-10106506-B2 | General process for the preparation of 6-substituted or 5,6-disubstituted derivatives of 2-amino-isonicotinic acid | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-10-23 | — | — | US | disclosed |
| US-20180186741-A1 | A GENERAL PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED OR 5,6-DISUBSTITUTED DERIVATIVES OF 2-AMINO-ISONICOTINIC ACID | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-07-05 | — | — | US | disclosed |
| US-20180186741-A1 | A GENERAL PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED OR 5,6-DISUBSTITUTED DERIVATIVES OF 2-AMINO-ISONICOTINIC ACID | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-07-05 | — | — | US | disclosed |
| EP-3317252-A1 | A GENERAL PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED OR 5,6-DISUBSTITUTED DERIVATIVES OF 2-AMINO-ISONICOTINIC ACID | Boehringer Ingelheim International GmbH (DE) | 2018-05-09 | — | — | EP | disclosed |
| WO-2017001670-A1 | A GENERAL PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED OR 5,6-DISUBSTITUTED DERIVATIVES OF 2-AMINO-ISONICOTINIC ACID | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-01-05 | — | — | WO | disclosed |
| EP-2227475-B1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | FIBROGEN INC (US) | 2014-02-19 | — | — | EP | disclosed |
| US-8269008-B2 | Oxazolopyridine and isoxazolopyridine derivatives for use in the treatment of HIF-mediated conditions | FIBROGEN, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-20100303928-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | FIBROGEN, INC. (US) | 2010-12-02 | — | — | US | disclosed |
| WO-2010117425-A1 | CERTAIN SUBSTITUTED PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | BIOGEN IDEC MA INC. (US) | 2010-10-14 | — | — | WO | disclosed |
| EP-2227475-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | Fibrogen, Inc. (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073669-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | FIBROGEN, INC. (US) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10106506-B2 | General process for the preparation of 6-substituted or 5,6-disubstituted derivatives of 2-amino-isonicotinic acid | IMPDH2, IMPDH1, GFPT1 | SOAT1 1840/4885ALDH1A1 678/4885NPSR1 2966/4885 |
| US-20100303928-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | HIF1AN, HIF1A, EGLN2 | SOAT1 4550/4885ALDH1A1 219/4885NPSR1 2642/4885 |
| US-20180186741-A1 | A GENERAL PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED OR 5,6-DISUBSTITUTED DERIVATIVES OF 2-AMINO-ISONICOTINIC ACID | IMPDH2, IMPDH1, GFPT1 | SOAT1 1862/4885ALDH1A1 699/4885NPSR1 2980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.