Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyproheptadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.90 |
| ▸ | SETD7 | Q8WTS6 | 7/20 | 0.90 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.90 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.90 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.90 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.90 |
| ▸ | HTR1A | P08908 | 4/20 | 0.90 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.90 |
| ▸ | DRD1 | P21728 | 4/20 | 0.90 |
| ▸ | DRD3 | P35462 | 4/20 | 0.90 |
| ▸ | HTR2A | P28223 | 4/20 | 0.90 |
| ▸ | HTR2C | P28335 | 4/20 | 0.90 |
| ▸ | HTR2B | P41595 | 4/20 | 0.90 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.90 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.90 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.90 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.90 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.90 |
| ▸ | DRD2 | P14416 | 3/20 | 0.90 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyproheptadine SCHEMBL3005524 | 0.98 | SETD7 (0.93) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Cyproheptadine SCHEMBL27756503 | 0.95 | LMNA (0.97) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Cyproheptadine SCHEMBL9934753 | 0.95 | LMNA (0.97) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Cyproheptadine SCHEMBL4021 | 0.95 | SETD7 (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Cyproheptadine SCHEMBL29369949 | 0.95 | SETD7 (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Cyproheptadine SCHEMBL7923153 | 0.95 | SETD7 (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Cyproheptadine SCHEMBL41842 | 0.93 | LMNA (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Cyproheptadine SCHEMBL20610743 | 0.93 | LMNA (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Cyproheptadine SCHEMBL29380652 | 0.93 | LMNA (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Cyproheptadine SCHEMBL5500354 | 0.93 | LMNA (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118121617-A | Drug-resistant group B streptococcus drug and application thereof | 绍兴文理学院附属医院 | 2024-06-04 | — | — | CN | disclosed |
| CN-112022827-B | Cyproheptadine hydrochloride quick-release pharmaceutical preparation and preparation method thereof | 上海信谊天平药业有限公司 | 2023-03-31 | — | — | CN | disclosed |
| WO-2022188898-A2 | USE OF CYPROHEPTADINE HYDROCHLORIDE COMPOUND IN PREPARATION OF DRUG FOR PREVENTING OR TREATING AFRICAN SWINE FEVER | 中国农业科学院兰州兽医研究所 | 2022-09-15 | — | — | WO | disclosed |
| CN-112552230-B | Synthetic method of cyproheptadine hydrochloride | 佛山普正医药科技有限公司 | 2022-08-26 | — | — | CN | disclosed |
| CN-114177176-B | Application of compound cyproheptadine hydrochloride in preparation of drug for preventing or treating African swine fever | 中国农业科学院兰州兽医研究所 | 2022-07-12 | — | — | CN | disclosed |
| CN-114177176-A | Application of compound cyproheptadine hydrochloride in preparation of drug for preventing or treating African swine fever | 中国农业科学院兰州兽医研究所 | 2022-03-15 | — | — | CN | disclosed |
| CN-112552230-A | Synthetic method of cyproheptadine hydrochloride | 佛山普正医药科技有限公司 | 2021-03-26 | — | — | CN | disclosed |
| CN-112022827-A | Cyproheptadine hydrochloride quick-release pharmaceutical preparation and preparation method thereof | 上海信谊天平药业有限公司 | 2020-12-04 | — | — | CN | disclosed |