Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MME | P08473 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 5/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 4/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | CPA1 | P15085 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CPB1 | P15086 | 1/20 | 0.40 |
| ▸ | CPA3 | P15088 | 1/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.40 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27954186 | 0.87 | CTSS (0.44) | MMEPPARGPPARACPA1CPB1 | |
| SCHEMBL27944378 | 0.85 | CTSL (0.47) | KMT2APPARGPPARACPA1MEN1 | |
| SCHEMBL4504708 | 0.84 | KMT2A (0.52) | KMT2AMMEPPARGEPHX2PPARA | |
| SCHEMBL1915429 | 0.84 | KMT2A (0.52) | KMT2AMMEPPARGEPHX2PPARA | |
| SCHEMBL1915428 | 0.84 | KMT2A (0.52) | KMT2AMMEPPARGEPHX2PPARA | |
| SCHEMBL27745166 | 0.82 | CYP3A4 (0.41) | KMT2AMMEPPARGEPHX2PPARA | |
| SCHEMBL27944387 | 0.80 | PPARG (0.41) | PPARGEPHX2PPARACPA1CPB1 | |
| SCHEMBL27954191 | 0.78 | CYP3A4 (0.43) | CPA1CPB1CPA3CPB2 | |
| SCHEMBL27613874 | 0.77 | CYP3A4 (0.41) | KMT2APPARGPPARA | |
| SCHEMBL27613846 | 0.77 | CYP3A4 (0.41) | KMT2APPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105130967-A | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors | ARRAY BIOPHARMA INC | 2015-12-09 | — | — | CN | disclosed |
| CN-103649076-B | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as TRKA kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2015-09-09 | — | — | CN | disclosed |
| CN-103649076-A | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors | ARRAY BIOPHARMA INC | 2014-03-19 | — | — | CN | disclosed |
| CN-102282141-A | Melanocortin receptor agonists | — | 2011-12-14 | — | — | CN | disclosed |
| CN-101535297-A | Melanocortin receptor agonists | LG LIFE SCIENCES LTD (KR) | 2009-09-16 | — | — | CN | disclosed |