Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 9/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.43 |
| ▸ | ANPEP | P15144 | 2/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 2/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | CPB1 | P15086 | 1/20 | 0.40 |
| ▸ | CPA3 | P15088 | 1/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30191579 | 0.85 | CYP3A4 (0.46) | CYP3A4TBXAS1ANPEPERAP1ERAP2 | |
| SCHEMBL22035309 | 0.85 | CYP3A4 (0.46) | CYP3A4TBXAS1ANPEPERAP1ERAP2 | |
| SCHEMBL27944378 | 0.79 | CTSL (0.47) | CPA1CPB1CPA3CPB2 | |
| SCHEMBL27756525 | 0.78 | KMT2A (0.48) | CPA1CPB1CPA3CPB2 | |
| SCHEMBL27954186 | 0.78 | CTSS (0.44) | CPA1CPB1CPA3CPB2 | |
| SCHEMBL27954184 | 0.78 | PTPRA (0.47) | FDPSCPA1CPB1CPA3CPB2 | |
| SCHEMBL2284531 | 0.78 | CYP3A4 (0.53) | CYP3A4TBXAS1ANPEPERAP1ERAP2 | |
| SCHEMBL20366127 | 0.77 | CPA1 (0.67) | TBXAS1ANPEPERAP1ERAP2FDPS | |
| SCHEMBL7384333 | 0.76 | CYP1A2 (0.62) | TBXAS1ANPEPERAP1ERAP2FDPS | |
| SCHEMBL27944387 | 0.76 | PPARG (0.41) | CPA1CPB1CPA3CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105130967-A | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors | ARRAY BIOPHARMA INC | 2015-12-09 | — | — | CN | disclosed |
| CN-103649076-B | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as TRKA kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2015-09-09 | — | — | CN | disclosed |
| CN-103649076-A | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors | ARRAY BIOPHARMA INC | 2014-03-19 | — | — | CN | disclosed |