Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.42 |
| ▸ | CPA1 | P15085 | 3/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | CPB1 | P15086 | 1/20 | 0.40 |
| ▸ | CPA3 | P15088 | 1/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1915659 | 0.85 | CTSL (0.51) | CTSLSLC7A5FOLH1CPA1PNMT | |
| SCHEMBL1915662 | 0.85 | CTSL (0.51) | CTSLSLC7A5FOLH1CPA1PNMT | |
| SCHEMBL27756525 | 0.85 | KMT2A (0.48) | CPA1CPB1CPA3CPB2PPARG | |
| SCHEMBL27954191 | 0.79 | CYP3A4 (0.43) | CPA1CPB1CPA3CPB2 | |
| SCHEMBL27944387 | 0.79 | PPARG (0.41) | FOLH1CPA1CPB1CPA3CPB2 | |
| SCHEMBL27954186 | 0.78 | CTSS (0.44) | CPA1CPB1CPA3CPB2PPARG | |
| SCHEMBL1185574 | 0.78 | CTSL (0.59) | CTSLSLC7A5FOLH1PNMTMEN1 | |
| SCHEMBL14885330 | 0.74 | CYP1A2 (0.55) | FOLH1PNMTPPARGPPARA | |
| SCHEMBL27954194 | 0.74 | CTSS (0.46) | FOLH1CPA1CPB1CPA3CPB2 | |
| SCHEMBL27954184 | 0.73 | PTPRA (0.47) | CPA1CPB1CPA3CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105130967-A | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors | ARRAY BIOPHARMA INC | 2015-12-09 | — | — | CN | disclosed |
| CN-103649076-B | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as TRKA kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2015-09-09 | — | — | CN | disclosed |
| CN-103649076-A | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors | ARRAY BIOPHARMA INC | 2014-03-19 | — | — | CN | disclosed |