Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 3/20 | 0.43 |
| ▸ | CPA1 | P15085 | 5/20 | 0.42 |
| ▸ | CPB1 | P15086 | 1/20 | 0.40 |
| ▸ | CPA3 | P15088 | 1/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27756525 | 0.87 | KMT2A (0.48) | MMECPA1CPB1CPA3CPB2 | |
| SCHEMBL1915658 | 0.84 | CTSS (0.47) | CTSSCTSKMMECPA1CPB1 | |
| SCHEMBL1915661 | 0.84 | CTSS (0.47) | CTSSCTSKMMECPA1CPB1 | |
| SCHEMBL27954194 | 0.80 | CTSS (0.46) | CTSSCTSKCPA1CPB1CPA3 | |
| SCHEMBL27944378 | 0.78 | CTSL (0.47) | CPA1CPB1CPA3CPB2PPARA | |
| SCHEMBL27954191 | 0.78 | CYP3A4 (0.43) | CPA1CPB1CPA3CPB2 | |
| SCHEMBL19377835 | 0.76 | MMP2 (0.48) | CTSSCTSKMMECPA1CPB1 | |
| SCHEMBL19377834 | 0.76 | MMP2 (0.48) | CTSSCTSKMMECPA1CPB1 | |
| SCHEMBL16798329 | 0.75 | CTSS (0.56) | CTSSCTSKPPARG | |
| SCHEMBL27944387 | 0.75 | PPARG (0.41) | CTSKCPA1CPB1CPA3CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105130967-A | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors | ARRAY BIOPHARMA INC | 2015-12-09 | — | — | CN | disclosed |
| CN-103649076-B | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as TRKA kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2015-09-09 | — | — | CN | disclosed |
| CN-103649076-A | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors | ARRAY BIOPHARMA INC | 2014-03-19 | — | — | CN | disclosed |