Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GLS | O94925 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14368710 | 1.00 | SIGMAR1 (0.55) | SIGMAR1CYP1A2CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL27757311 | 0.90 | C3AR1 (0.50) | SIGMAR1ALDH1A1MAPTHTTC3AR1 | |
| SCHEMBL14368761 | 0.90 | C3AR1 (0.50) | SIGMAR1ALDH1A1MAPTHTTC3AR1 | |
| SCHEMBL28944413 | 0.87 | EPHX2 (0.56) | SIGMAR1ALDH1A1GLSEPHX2 | |
| SCHEMBL14368746 | 0.87 | EPHX2 (0.56) | SIGMAR1ALDH1A1GLSEPHX2 | |
| SCHEMBL28783273 | 0.80 | POLB (0.58) | SIGMAR1ALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL14368730 | 0.80 | POLB (0.58) | SIGMAR1ALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL23972940 | 0.78 | EPHX2 (0.68) | SIGMAR1CYP1A2CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL14368687 | 0.77 | EPHX2 (0.60) | SIGMAR1CYP1A2CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL14368812 | 0.76 | LMNA (0.55) | ALDH1A1MAPTHTTKDM4EHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101484442-A | Compounds that are agonists of muscarinic receptors and tha may be effective in treating pain, alzheimer's disease and/or schizophrenia | ASTRAZENECA AB (SE) | 2009-07-15 | — | — | CN | claimed |
| CN-101484442-A | Compounds that are agonists of muscarinic receptors and tha may be effective in treating pain, alzheimer's disease and/or schizophrenia | ASTRAZENECA AB (SE) | 2009-07-15 | — | — | CN | disclosed |