Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 8/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL5854822 | 1.00 | HCAR2 (0.52) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL28225492 | 1.00 | HCAR2 (0.52) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL11785692 | 0.88 | HCAR2 (0.42) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Monomethyl Fumarate SCHEMBL11322975 | 0.88 | HCAR2 (0.63) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Monomethyl Fumarate SCHEMBL11322974 | 0.88 | HCAR2 (0.63) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL11782248 | 0.88 | HCAR2 (0.42) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Acrylic Acid SCHEMBL28659504 | 0.88 | LMNA (0.50) | HCAR2TSHRTP53LMNAALDH1A1 | |
| Bicarbonate SCHEMBL28785631 | 0.87 | — | — | |
| Acetic Acid SCHEMBL6676468 | 0.85 | — | — | |
| Acrylic Acid SCHEMBL29073994 | 0.84 | LMNA (0.46) | HCAR2TSHRLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6896903-B2 | Bioadhesive compositions | FIRST WATER LIMITED (GB) | 2005-05-24 | — | — | US | claimed |
| EP-1163309-B1 | BIOADHESIVE COMPOSITIONS | FIRST WATER LTD (GB) | 2004-06-09 | — | — | EP | claimed |
| US-20020026005-A1 | Bioadhesive compositions | FIRST WATER LIMITED (GB) | 2002-02-28 | — | — | US | claimed |
| US-20020015689-A1 | Bioadhesive compositions | FIRST WATER LIMITED (GB) | 2002-02-07 | — | — | US | claimed |
| EP-1163309-A1 | BIOADHESIVE COMPOSITIONS | First Water Limited (GB) | 2001-12-19 | — | — | EP | claimed |
| EP-1150721-A1 | BIOADHESIVE COMPOSITIONS | First Water Limited (GB) | 2001-11-07 | — | — | EP | claimed |
| WO-2000046319-A1 | BIOADHESIVE COMPOSITIONS | FIRST WATER LIMITED (GB) | 2000-08-10 | — | — | WO | claimed |
| WO-2000045864-A1 | BIOADHESIVE COMPOSITIONS | FIRST WATER LIMITED (GB) | 2000-08-10 | — | — | WO | claimed |
| EP-1026219-A1 | Bioadhesive compositions | First Water Limited (GB) | 2000-08-09 | — | — | EP | claimed |
| US-11369553-B2 | Therapeutic oral composition | COLGATE-PALMOLIVE COMPANY (US) | 2022-06-28 | — | — | US | disclosed |
| US-20170128340-A1 | THERAPEUTIC ORAL COMPOSITION | COLGATE-PALMOLIVE COMPANY (US) | 2017-05-11 | — | — | US | disclosed |
| US-20120052025-A1 | BORINIC COMPOSITIONS | COLGATE-PALMOLIVE COMPANY (US) | 2012-03-01 | — | — | US | disclosed |
| US-7152601-B2 | Strapless respiratory face mask | Barakat, Mohamed Ali (IT) | 2006-12-26 | — | — | US | disclosed |
| EP-1313414-B1 | ANTI-SNORING DEVICE COMPRISING A SKIN COMPATIBLE ADHESIVE | BARAKAT MOHAMED ALI (BE) | 2006-08-23 | — | — | EP | disclosed |
| EP-1026219-A1 | Bioadhesive compositions | First Water Limited (GB) | 2000-08-09 | — | — | EP | disclosed |
| EP-1025867-A1 | Disposable human waste management devices with improved adhesive flange to facilitate adhesion in oily conditions | THE PROCTER & GAMBLE COMPANY (US) | 2000-08-09 | — | — | EP | disclosed |
| EP-1025824-A1 | Disposable human waste management devices with improved adhesive flange | THE PROCTER & GAMBLE COMPANY (US) | 2000-08-09 | — | — | EP | disclosed |
| EP-1014921-A1 | ENZYMATIC FOAM COMPOSITIONS FOR DYEING KERATINOUS FIBRES | NOVO NORDISK A/S (DK) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999015137-A1 | ENZYMATIC FOAM COMPOSITIONS FOR DYEING KERATINOUS FIBRES | NOVO NORDISK A/S (DK) | 1999-04-01 | — | — | WO | disclosed |
| EP-0177765-B1 | SILVER HALIDE COLOR PHOTOGRAPHIC MATERIAL | FUJI PHOTO FILM CO., LTD. (JP) | 1990-03-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020015689-A1 | Bioadhesive compositions | EPCAM, PHOSPHO1, DSG1 | HCAR2 3185/4885TSHR 4376/4885TP53 2003/4885 |
| US-20120052025-A1 | BORINIC COMPOSITIONS | CCL11, BDKRB2, BTD | HCAR2 676/4885TSHR 4588/4885TP53 3849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.