Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | SCN1A | P35498 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.52 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6679644 | 0.87 | ACHE (0.48) | ALDH1A1HRH3MAPK1SIGMAR1CYP1A2 | |
| SCHEMBL2776315 | 0.80 | ALDH1A1 (0.53) | ALDH1A1HRH3MAPK1SIGMAR1CYP1A2 | |
| SCHEMBL6029115 | 0.80 | ALDH1A1 (0.57) | ALDH1A1HRH3MAPK1SIGMAR1CYP1A2 | |
| SCHEMBL2777464 | 0.76 | FGFR1 (0.40) | ALDH1A1HRH3FGFR1SRCKDM4E | |
| SCHEMBL6675614 | 0.73 | CRHBP (0.41) | ALDH1A1CYP1A2LMNAKDM4EHTT | |
| SCHEMBL6674324 | 0.72 | PIK3CA (0.48) | ALDH1A1CYP1A2USP2LMNAKDM4E | |
| SCHEMBL2245987 | 0.72 | TMEM97 (0.33) | SIGMAR1 | |
| SCHEMBL13186317 | 0.72 | HRH3 (0.80) | ALDH1A1HRH3MAPK1SIGMAR1CYP1A2 | |
| SCHEMBL6674330 | 0.72 | KDM4E (0.55) | ALDH1A1FGFR1SRCKDM4ETSHR | |
| SCHEMBL6674667 | 0.72 | KDM4E (0.49) | ALDH1A1FGFR1SRCKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816521-B2 | 1,2,4-benzotriazine-1,4-dioxides | AUCKLAND UNISERVICES LIMITED (NZ) | 2010-10-19 | — | — | US | disclosed |
| US-7816521-B2 | 1,2,4-benzotriazine-1,4-dioxides | AUCKLAND UNISERVICES LIMITED (NZ) | 2010-10-19 | — | — | US | disclosed |
| US-20070197534-A1 | Novel 1,2,4-benzotriazine-1,4-dioxides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-08-23 | — | — | US | disclosed |
| US-20070197534-A1 | Novel 1,2,4-benzotriazine-1,4-dioxides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-08-23 | — | — | US | disclosed |
| EP-1723125-A1 | NOVEL 1,2,4-BENZOTRIAZINE-1,4-DIOXIDES | Auckland Uniservices Limited (NZ) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005082867-A1 | NOVEL 1,2,4-BENZOTRIAZINE-1,4-DIOXIDES | AUCKLAND UNISERVICES LIMITED (NZ) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197534-A1 | Novel 1,2,4-benzotriazine-1,4-dioxides | HIF1AN, HIF1A, HYOU1 | ALDH1A1 1013/4885HRH3 786/4885MAPK1 4221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.