SCHEMBL6029115

SCHEMBL6029115

CCc1nnc2ccc(OCCCN3CCOCC3)cc2n1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.57
MAPK1 P28482 2/20 0.57
HRH3 Q9Y5N1 2/20 0.57
SIGMAR1 Q99720 2/20 0.57
CYP1A2 P05177 1/20 0.57
CHRM2 P08172 1/20 0.57
CHRM1 P11229 1/20 0.57
HTR2A P28223 1/20 0.57
SCN1A P35498 1/20 0.57
HTR2B P41595 1/20 0.57
KCNH2 Q12809 1/20 0.57
SCN2A Q99250 1/20 0.57
SCN3A Q9NY46 1/20 0.57
USP2 O75604 1/20 0.56
LMNA P02545 1/20 0.56
KDM4E B2RXH2 1/20 0.51
HTT P42858 1/20 0.51
FGFR1 P11362 2/20 0.51
SRC P12931 2/20 0.51
MIF P14174 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2776140 0.80 ALDH1A1 (0.52) ALDH1A1MAPK1HRH3SIGMAR1CYP1A2
SCHEMBL22529604 0.78 ALDH1A1 (0.55) ALDH1A1MAPK1HRH3SIGMAR1CYP1A2
SCHEMBL6679644 0.76 ACHE (0.48) ALDH1A1MAPK1HRH3SIGMAR1CYP1A2
SCHEMBL22529705 0.76 HRH3 (0.52) ALDH1A1MAPK1HRH3SIGMAR1CYP1A2
Pramoxine SCHEMBL26020 0.74 ALDH1A1 (1.00) ALDH1A1MAPK1HRH3SIGMAR1CYP1A2
SCHEMBL29508184 0.74 ALDH1A1 (0.81) ALDH1A1MAPK1HRH3SIGMAR1CYP1A2
SCHEMBL6652253 0.74 DRD3 (0.58) ALDH1A1MAPK1HRH3SIGMAR1CYP1A2
SCHEMBL13186317 0.73 HRH3 (0.80) ALDH1A1MAPK1HRH3SIGMAR1CYP1A2
SCHEMBL21642566 0.73 KDM4E (0.65) ALDH1A1KDM4EFGFR1SRCTSHR
SCHEMBL23804878 0.73 HRH3 (0.91) ALDH1A1MAPK1HRH3SIGMAR1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1723125-A1 NOVEL 1,2,4-BENZOTRIAZINE-1,4-DIOXIDES Auckland Uniservices Limited (NZ) 2006-11-22 EP claimed
WO-2005082867-A1 NOVEL 1,2,4-BENZOTRIAZINE-1,4-DIOXIDES AUCKLAND UNISERVICES LIMITED (NZ) 2005-09-09 WO claimed
EP-1723125-A1 NOVEL 1,2,4-BENZOTRIAZINE-1,4-DIOXIDES Auckland Uniservices Limited (NZ) 2006-11-22 EP disclosed
WO-2005082867-A1 NOVEL 1,2,4-BENZOTRIAZINE-1,4-DIOXIDES AUCKLAND UNISERVICES LIMITED (NZ) 2005-09-09 WO disclosed