Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.43 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | DHX9 | Q08211 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31108381 | 1.00 | POLB (0.53) | POLBALDH1A1SMN1; SMN2DRD2DRD4 | |
| SCHEMBL4204011 | 0.81 | PGR (0.62) | POLBALDH1A1SMN1; SMN2DRD2DRD4 | |
| SCHEMBL309673 | 0.80 | LMNA (0.60) | POLBALDH1A1SMN1; SMN2DRD2DRD4 | |
| SCHEMBL27802670 | 0.80 | PGR (0.56) | ALDH1A1SMN1; SMN2DRD3KEAP1PGR | |
| SCHEMBL27363449 | 0.78 | POLB (0.53) | POLBALDH1A1SMN1; SMN2DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL20502482 | 0.78 | LMNA (0.59) | POLBALDH1A1SMN1; SMN2DRD2DRD4 | |
| SCHEMBL28346861 | 0.78 | L3MBTL1 (0.56) | ALDH1A1SMN1; SMN2BRD4HSD17B2F2 | |
| SCHEMBL27710671 | 0.78 | APP (0.45) | POLBALDH1A1SMN1; SMN2MEN1PKM | |
| SCHEMBL28058379 | 0.77 | KIF11 (0.60) | POLBKIF11NR3C1 | |
| SCHEMBL190004 | 0.77 | SMN1; SMN2 (0.54) | POLBALDH1A1SMN1; SMN2DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105828820-B | Bromodomain inhibitors | 赛尔基因昆蒂赛尔研究公司 | 2020-01-07 | — | — | CN | disclosed |
| CN-110214012-A | Azole pyrimidines for the treatment of cancer-related diseases | 艾库斯生物科学有限公司 | 2019-09-06 | — | — | CN | disclosed |
| CN-104703979-B | Heterocyclic compounds and their use | 无限药品股份有限公司 | 2018-11-27 | — | — | CN | disclosed |
| CN-105102449-B | Antiviral compound | 豪夫迈·罗氏有限公司 | 2017-06-13 | — | — | CN | disclosed |
| CN-104583215-B | Diene also-and piperazine-[2,3-D] pyrimidine PI3K inhibitor compound and using method | 霍夫曼-拉罗奇有限公司 | 2016-12-07 | — | — | CN | disclosed |
| CN-103690542-B | Poly-(ADP-ribose) AG14361 | ABBVIE INC. (US) | 2015-11-18 | — | — | CN | disclosed |
| CN-103690542-A | Inhibitors of poly(ADP-ribose)polymerase | ABBVIE INC | 2014-04-02 | — | — | CN | disclosed |
| CN-101808983-B | Biaryl sulfonamide derivatives | HOFFMANN LA ROCHE | 2013-11-13 | — | — | CN | disclosed |
| CN-102574845-A | 1h-imidazo[4,5-c]quinolinone derivatives | NOVARTIS AG | 2012-07-11 | — | — | CN | disclosed |
| CN-102458122-A | Compounds, compositions and methods comprising pyridazine sulfonamide derivatives | INST ONEWORLD HEALTH | 2012-05-16 | — | — | CN | disclosed |
| CN-102333757-A | N-acyl anthranilic acid derivative or salt thereof | TOYAMA CHEMICAL CO LTD | 2012-01-25 | — | — | CN | disclosed |
| CN-101932587-A | Thiazole and pyrimidine PI3K inhibitor compound and using method | GENENTECH INC | 2010-12-29 | — | — | CN | disclosed |
| CN-101808983-A | biaryl sulfonamide derivatives | HOFFMANN LA ROCHE | 2010-08-18 | — | — | CN | disclosed |
| CN-101675053-A | Phosphoinositide 3-kinase inhibitor compounds and methods of use | GENENTECH INC | 2010-03-17 | — | — | CN | disclosed |
| CN-101641014-A | Poly (ADP-ribose) polymerase inhibitors | ABBOTT LAB US | 2010-02-03 | — | — | CN | disclosed |
| CN-101511840-A | Phosphoinositide 3-kinase inhibitor compounds and methods of use thereof | GENENTECH INC (US) | 2009-08-19 | — | — | CN | disclosed |
| CN-101443013-A | Pyrazolo [3, 4-d ] pyrimidine derivatives for the treatment of respiratory disorders | NOVARTIS AG (CH) | 2009-05-27 | — | — | CN | disclosed |