Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 5/20 | 0.70 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.70 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menthol SCHEMBL15135044 | 0.94 | TRPM8 (0.62) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL4335212 | 0.93 | TRPM8 (0.81) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL1664554 | 0.91 | TRPM8 (0.84) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL17204733 | 0.90 | TRPM8 (0.70) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL28984675 | 0.86 | TRPM8 (0.75) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL1664660 | 0.86 | TRPM8 (0.81) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL20586546 | 0.86 | TRPM8 (0.81) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL15135035 | 0.85 | TRPM8 (0.68) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL583696 | 0.85 | TRPM8 (0.72) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Levomenthol SCHEMBL2961481 | 0.85 | TRPM8 (0.72) | TRPM8TRPA1EPHX1KCNA5TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101448405-B | Compressed gum and process for the preparation thereof | WRIGLEY W M JUN CO | 2013-03-06 | — | — | CN | disclosed |
| CN-101448405-A | Compressed gum and process for the preparation thereof | WRIGLEY W M JUN CO (US) | 2009-06-03 | — | — | CN | disclosed |