Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 5/20 | 0.81 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.81 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menthol SCHEMBL27764261 | 0.93 | TRPM8 (0.70) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Menthol SCHEMBL19551414 | 0.90 | TRPM8 (0.91) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL12646785 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Isomenthol SCHEMBL677675 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL9968934 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL13059620 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL15449169 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Racementhol SCHEMBL521946 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Menthol SCHEMBL20771511 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+) Neomenthol SCHEMBL260049 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885275-A1 | TOPICAL WARMING COMPOSITION | Takasago International Corporation (USA) (US) | 2008-02-13 | — | — | EP | claimed |
| WO-2006130710-A1 | TOPICAL WARMING COMPOSITION | TAKASAGO INTERNATIONAL CORP. (USA) (US) | 2006-12-07 | — | — | WO | claimed |
| WO-2023083445-A1 | COMPOSITIONS COMPRISING TRPM8 AGONISTIC COOLING AGENTS | SYMRISE AG (DE) | 2023-05-19 | — | — | WO | disclosed |
| EP-3356356-B1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED (US) | 2021-05-26 | — | — | EP | disclosed |
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2019-08-27 | — | — | US | disclosed |
| US-20190177308-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. | 2019-06-13 | — | — | US | disclosed |
| US-20180273517-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX INC (US) | 2018-09-27 | — | — | US | disclosed |
| EP-3356356-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2018-08-08 | — | — | EP | disclosed |
| US-9732071-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2017-08-15 | — | — | US | disclosed |
| CN-104642983-B | One kind compounding coolant agent composition and its preparation technology | 昆山亚香香料股份有限公司 | 2017-06-16 | — | — | CN | disclosed |
| US-20170096418-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED | 2017-04-06 | — | — | US | disclosed |
| US-20160376263-A1 | BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF | SENOMYX INC (US) | 2016-12-29 | — | — | US | disclosed |
| US-20160339026-A1 | TOPICAL COMPOSITIONS COMPRISING MODULATORS OF TRPM8 | SENOMYX INC (US) | 2016-11-24 | — | — | US | disclosed |
| CN-104642983-A | Compound cooling agent composition and preparation technology thereof | KUNSHAN ASIA AROMA CO LTD | 2015-05-27 | — | — | CN | disclosed |
| US-20140335224-A1 | COOLING COMPOSITION | SYMRISE AG (DE) | 2014-11-13 | — | — | US | disclosed |
| WO-2009012131-A2 | FLAVOR BEAD COMPOSITIONS | WM. WRIGLEY JR. COMPANY (US) | 2009-01-22 | — | — | WO | disclosed |
| EP-1353653-A4 | CHEWING GUMS AND RELATED PRODUCTS THAT PROVIDE BREATH FRESHENING CHARACTERISTICS | WRIGLEY W M JUN CO (US) | 2008-10-29 | — | — | EP | disclosed |
| US-7087255-B2 | Chewing gums that provide breath freshening characteristics | WM. WRIGLEY JR. COMPANY (US) | 2006-08-08 | — | — | US | disclosed |
| EP-1353653-A1 | CHEWING GUMS AND RELATED PRODUCTS THAT PROVIDE BREATH FRESHENING CHARACTERISTICS | WM. WRIGLEY JR. COMPANY (US) | 2003-10-22 | — | — | EP | disclosed |
| WO-2002051392-A1 | CHEWING GUMS AND RELATED PRODUCTS THAT PROVIDE BREATH FRESHENING CHARACTERISTICS | WM. WRIGLEY JR. COMPANY (US) | 2002-07-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160376263-A1 | BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF | TAS2R5, TAS1R1, TAS2R1 | TRPM8 70/4885TRPA1 16/4885EPHX1 3681/4885 |
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM4, TRPM6 | TRPM8 1/4885TRPA1 8/4885EPHX1 4010/4885 |
| US-20190177308-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | TRPM8 1/4885TRPA1 8/4885EPHX1 3982/4885 |
| US-20180273517-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | TRPM8 1/4885TRPA1 8/4885EPHX1 3982/4885 |
| US-20160339026-A1 | TOPICAL COMPOSITIONS COMPRISING MODULATORS OF TRPM8 | TRPM8, TRPM7, TRPM2 | TRPM8 1/4885TRPA1 9/4885EPHX1 3138/4885 |
| US-20170096418-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | TRPM8 1/4885TRPA1 8/4885EPHX1 3982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.