Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 4/20 | 0.72 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.72 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levomenthol SCHEMBL2961481 | 1.00 | TRPM8 (0.72) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL15135035 | 0.97 | TRPM8 (0.68) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL1664554 | 0.93 | TRPM8 (0.84) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL3648445 | 0.93 | TRPM8 (0.84) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL15135044 | 0.92 | TRPM8 (0.62) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL27906472 | 0.91 | TRPM8 (0.81) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL583835 | 0.90 | TRPM8 (0.68) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Levomenthol SCHEMBL2960650 | 0.90 | TRPM8 (0.68) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL2671170 | 0.90 | TRPM8 (0.72) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL20482244 | 0.89 | TRPM8 (0.78) | TRPM8TRPA1EPHX1KCNA5TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 704 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12369600-B2 | Cooling composition | SYMRISE AG (DE) | 2025-07-29 | — | — | US | claimed |
| US-20250163006-A1 | New Coolants, and Preparations Containing Same | SYMRISE AG (DE) | 2025-05-22 | — | — | US | claimed |
| US-20250066320-A1 | Active Ingredients with Sialagogue and Tingling/Fizzy Effect, and Preparations Containing Same | SYMRISE AG (DE) | 2025-02-27 | — | — | US | claimed |
| WO-2025026525-A1 | HETEROCYCLIC COMPOUNDS AS PHYSIOLOGICAL COOLANTS | SYMRISE AG (DE) | 2025-02-06 | — | — | WO | claimed |
| EP-4501125-A2 | MIXTURES CONTAINING (E)-3-BENZO[1, 3 -DIOXOL-5-YL-N,N-DIPHENYL-2-PROPENAMIDE | Symrise AG (DE) | 2025-02-05 | — | — | EP | claimed |
| EP-4469439-A1 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | Symrise AG (DE) | 2024-12-04 | — | — | EP | claimed |
| EP-3496698-B1 | MIXTURES COMPRISING (3)-BENZO(1,3)DIOXOL-5-YL-N,N-DIPHENYLE-2-PROPENAMIDE | SYMRISE AG (DE) | 2024-11-20 | — | — | EP | claimed |
| EP-3689324-B1 | NEW COOLING AGENTS AND PREPARATIONS COMPRISING THEM | SYMRISE AG (DE) | 2024-11-20 | — | — | EP | claimed |
| CN-118984825-A | Novel cooling agent and preparation containing same | 西姆莱斯股份公司 | 2024-11-19 | — | — | CN | claimed |
| EP-4452941-A1 | ACTIVE INGREDIENTS WITH SIALAGOGUE AND TINGLING/FIZZY EFFECT, AND PREPARATIONS CONTAINING SAME | Symrise AG (DE) | 2024-10-30 | — | — | EP | claimed |
| WO-2007004740-A1 | VANILLIN ACETALS AND SENSORY STIMULANT COMPOSITION CONTAINING THE SAME | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2007-01-11 | — | — | WO | claimed |
| WO-2006137556-A1 | FLAVOR AND FRAGRANCE COMPOSITION | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2006-12-28 | — | — | WO | claimed |
| WO-2006130710-A1 | TOPICAL WARMING COMPOSITION | TAKASAGO INTERNATIONAL CORP. (USA) (US) | 2006-12-07 | — | — | WO | claimed |
| US-20060269500-A1 | Topical warming composition | TAKASAGO INTERNATIONAL CORP. (USA) (US) | 2006-11-30 | — | — | US | claimed |
| US-20060217456-A1 | Non-toxic coating composition, methods of use thereof and articles protected from attachment of biofouling organisms | SYMRISE GMBH & CO. KG (DE) | 2006-09-28 | — | — | US | claimed |
| EP-1615974-A1 | NON-TOXIC COATING COMPOSITION, METHODS OF USE THEREOF AND ARTICLES PROTECTED FROM ATTACHMENT OF BIOFOULING ORGANISMS | Symrise GmbH & Co. KG (DE) | 2006-01-18 | — | — | EP | claimed |
| WO-2004090052-A1 | NON-TOXIC COATING COMPOSITION, METHODS OF USE THEREOF AND ARTICLES PROTECTED FROM ATTACHMENT OF BIOFOULING ORGANISMS | SYMRISE GMBH & CO. KG (DE) | 2004-10-21 | — | — | WO | claimed |
| EP-1466949-A1 | Non-toxic coating composition, methods of use thereof and articles protected from attachment of biofouling organisms | Symrise GmbH & Co. KG (DE) | 2004-10-13 | — | — | EP | claimed |
| EP-1461057-A1 | A TOPICAL ANTI-ITCH FORMULATION AND A PROCESS FOR THE PREPARATION THEREOF | Johnson & Johnson Limited (IN) | 2004-09-29 | — | — | EP | claimed |
| WO-2003047609-A1 | A TOPICAL ANTI-ITCH FORMULATION AND A PROCESS FOR THE PREPARATION THEREOF | JOHNSON & JOHNSON LIMITED (IN) | 2003-06-12 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060269500-A1 | Topical warming composition | CUTA, NACA, LSM14A | TRPM8 379/4885TRPA1 68/4885EPHX1 1485/4885 |
| US-12369600-B2 | Cooling composition | TAS2R5, TAS2R20, TAS2R60 | TRPM8 362/4885TRPA1 584/4885EPHX1 3279/4885 |
| US-20250066320-A1 | Active Ingredients with Sialagogue and Tingling/Fizzy Effect, and Preparations Containing Same | TAS2R5, TAS2R7, TAS2R8 | TRPM8 363/4885TRPA1 1499/4885EPHX1 2617/4885 |
| US-20250163006-A1 | New Coolants, and Preparations Containing Same | TTR, TAS2R5, TAS2R50 | TRPM8 152/4885TRPA1 185/4885EPHX1 2081/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.