SCHEMBL2776491

SCHEMBL2776491

Nc1ccc2c(c1)N(c1ccccc1)c1cc(N)ccc1N2

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GNG2 P59768 2/20 0.53
GNB1 P62873 2/20 0.53
ALDH1A1 P00352 6/20 0.40
KDM4E B2RXH2 5/20 0.40
MAPT P10636 3/20 0.40
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
STAT1 P42224 1/20 0.40
GAA P10253 1/20 0.40
GFER P55789 2/20 0.39
LMNA P02545 1/20 0.39
MAPK1 P28482 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
CYP1A2 P05177 1/20 0.38
CYP2D6 P10635 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
CHRM1 P11229 1/20 0.37
FGFR1 P11362 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30664408 1.00 GNG2 (0.53) GNG2GNB1ALDH1A1KDM4EMAPT
Hydrochloric Acid SCHEMBL29845954 0.98 GNG2 (0.51) GNG2GNB1ALDH1A1KDM4EMAPT
Hydrochloric Acid SCHEMBL28854046 0.98 GNG2 (0.51) GNG2GNB1ALDH1A1KDM4EMAPT
Hydrochloric Acid SCHEMBL31571625 0.92 GNG2 (0.47) GNG2GNB1ALDH1A1KDM4EMAPT
SCHEMBL13320813 0.91 ALDH1A1 (0.46) GNG2GNB1ALDH1A1KDM4EMAPT
SCHEMBL6158102 0.88 GNG2 (0.44) GNG2GNB1ALDH1A1KDM4EMAPT
SCHEMBL13891631 0.87 GNG2 (0.43) GNG2GNB1ALDH1A1KDM4EMAPT
SCHEMBL28854045 0.83 GNG2 (0.40) GNG2GNB1ALDH1A1KDM4EMAPT
SCHEMBL3130473 0.83 L3MBTL1 (0.42) GNG2GNB1ALDH1A1KDM4EMAPT
SCHEMBL2848413 0.82 GNG2 (0.39) GNG2GNB1ALDH1A1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120258548-A1 REDOX SENSOR TUFTS UNIVERSITY (US) 2012-10-11 US claimed
US-20100130505-A1 COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING UNIVERSITY OF ROCHESTER (US) 2010-05-27 US claimed
JP-58038781-A None JP disclosed
CN-116930285-A Biosensor and method for manufacturing biosensor 爱科来株式会社 2023-10-24 CN disclosed
US-10619178-B2 Biosensor and production method for same ARKRAY, INC. (JP) 2020-04-14 US disclosed
EP-3290523-B1 BIOSENSOR AND PRODUCTION METHOD FOR SAME ARKRAY INC (JP) 2019-01-23 EP disclosed
EP-3290523-A1 BIOSENSOR AND PRODUCTION METHOD FOR SAME ARKRAY, Inc. (JP) 2018-03-07 EP disclosed
US-20180057851-A1 Biosensor and Production Method for Same ARKRAY, INC. (JP) 2018-03-01 US disclosed
US-8975259-B2 Compositions and methods for inhibiting G protein signaling UNIVERSITY OF ROCHESTER (US) 2015-03-10 US disclosed
US-8975259-B2 Compositions and methods for inhibiting G protein signaling UNIVERSITY OF ROCHESTER (US) 2015-03-10 US disclosed
US-20120258548-A1 REDOX SENSOR TUFTS UNIVERSITY (US) 2012-10-11 US disclosed
US-20030166295-A1 Method for measuring substance and testing piece FUKUOKA TAKAO (JP) 2003-09-04 US disclosed
US-20030044316-A1 Specimen having capability of separating solid component ARKRAY INC. (JP) 2003-03-06 US disclosed
EP-1271143-A1 SPECIMEN HAVING CAPABILITY OF SEPARATING SOLID COMPONENT ARKRAY, Inc. (JP) 2003-01-02 EP disclosed
EP-0860695-A9 METHOD OF MEASUREMENT OF MATERIAL AND TESTPIECE KABUSHIKI KAISHA KYOTO DAIICHI KAGAKU (JP) 2001-10-17 EP disclosed
EP-0860695-A1 METHOD OF MEASUREMENT OF MATERIAL AND TESTPIECE KABUSHIKI KAISHA KYOTO DAIICHI KAGAKU (JP) 1998-08-26 EP disclosed
JP-S5838781-A ELECTROCHROMIC DISPLAY ELEMENT JAPAN ELECTRONIC IND DEV ASSOC<JEIDA> 1983-03-07 JP disclosed
US-4012292-A ELECTRICAL CANON KABUSHIKI KAISHA (JA) 1977-03-15 US disclosed
US-3974041-A Image recording member with zeolitic water containing compounds CANON KABUSHIKI KAISHA (JA) 1976-08-10 US disclosed
US-3936361-A ELECTROCONDUCTIVITY TAKATORI YASUSHI 1976-02-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100130505-A1 COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING GNAI1, GNAI3, GNAI2 GNG2 5/4885GNB1 4/4885ALDH1A1 4720/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.