Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2776959 | 0.95 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2GAAACHEMAPT | |
| SCHEMBL2777530 | 0.88 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2GAAACHEMAPT | |
| SCHEMBL2778693 | 0.85 | ACHE (0.41) | ACHE | |
| SCHEMBL2778779 | 0.80 | PNMT (0.46) | ALDH1A1SMN1; SMN2MAPK1GRIN2BPNMT | |
| SCHEMBL2777018 | 0.80 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2GAAACHE | |
| SCHEMBL2777417 | 0.79 | ACHE (0.41) | ACHE | |
| SCHEMBL2776754 | 0.77 | PNMT (0.42) | ALDH1A1SMN1; SMN2GRIN2BPNMTSIRT2 | |
| SCHEMBL2777418 | 0.76 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2GAAMAPTMAPK1 | |
| SCHEMBL2776821 | 0.76 | ACHE (0.36) | ALDH1A1ACHEMAPT | |
| SCHEMBL2776739 | 0.74 | ACHE (0.44) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139886-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | Neuraxon Inc. (CA) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008116308-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2008-10-02 | — | — | WO | disclosed |