Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 5/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2776785 | 0.91 | PNMT (0.43) | PNMTADRA2AADRA2BADRA2CAR | |
| SCHEMBL2778779 | 0.84 | PNMT (0.46) | PNMTADRA2AADRA2BADRA2CAR | |
| SCHEMBL7456470 | 0.83 | PNMT (0.56) | PNMTADRA2AADRA2BADRA2CAR | |
| SCHEMBL6195263 | 0.82 | SIRT2 (0.45) | PNMTADRA2AADRA2BADRA2CSIRT2 | |
| SCHEMBL2776959 | 0.81 | ALDH1A1 (0.42) | SIRT2ALDH1A1SMN1; SMN2GRIN2B | |
| SCHEMBL6197463 | 0.81 | PNMT (0.54) | PNMTADRA2AADRA2BADRA2CSIRT2 | |
| SCHEMBL2775909 | 0.79 | PNMT (0.33) | PNMTADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL2776745 | 0.77 | ALDH1A1 (0.41) | PNMTSIRT2ALDH1A1SMN1; SMN2GRIN2B | |
| SCHEMBL2857664 | 0.76 | ALDH1A1 (0.52) | PNMTADRA2AADRA2BADRA2CSIRT2 | |
| Bicarbonate SCHEMBL8143271 | 0.74 | MAPK1 (0.40) | PNMTADRA2AADRA2BADRA2CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139886-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | Neuraxon Inc. (CA) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008116308-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2008-10-02 | — | — | WO | disclosed |