Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.43 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ATP4A | P20648 | 2/20 | 0.41 |
| ▸ | ATP4B | P51164 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
| ▸ | RRM1 | P23921 | 1/20 | 0.40 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3610888 | 0.82 | ABL1 (0.54) | ABL1HSPD1HSPE1MEN1KMT2A | |
| SCHEMBL3599324 | 0.82 | ABL1 (0.57) | ABL1HSPD1HSPE1MEN1KMT2A | |
| SCHEMBL3607108 | 0.82 | ABL1 (0.49) | ABL1HSPD1HSPE1MEN1KMT2A | |
| SCHEMBL3602906 | 0.81 | MEN1 (0.58) | MEN1KMT2AALDH1A1ALOX15MAPK1 | |
| SCHEMBL27768308 | 0.80 | AOC3 (0.50) | ABL1MEN1KMT2AALDH1A1ALOX15 | |
| SCHEMBL3604738 | 0.79 | MEN1 (0.61) | MEN1KMT2AALDH1A1ALOX15MAPK1 | |
| SCHEMBL2395281 | 0.79 | ATP4A (0.49) | ABL1MEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL3604799 | 0.78 | ALOX5 (0.61) | ABL1HSPD1HSPE1MEN1KMT2A | |
| SCHEMBL3597550 | 0.78 | RRM1 (0.64) | ABL1HSPD1HSPE1MEN1KMT2A | |
| SCHEMBL2393684 | 0.76 | HDAC3 (0.59) | ABL1HSPD1HSPE1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466692-A | Thiazol-guanidine derivatives useful as a (beta) - related pathologies | ASTRAZENECA AB (SE) | 2009-06-24 | — | — | CN | claimed |
| CN-101466692-A | Thiazol-guanidine derivatives useful as a (beta) - related pathologies | ASTRAZENECA AB (SE) | 2009-06-24 | — | — | CN | disclosed |