Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | CHIT1 | Q13231 | 2/20 | 0.34 |
| ▸ | CHIA | Q9BZP6 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 3/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | KHK | P50053 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.30 |
| ▸ | FEN1 | P39748 | 2/20 | 0.30 |
| ▸ | INSR | P06213 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL467478 | 0.80 | AXL (0.42) | AXLGAAINSRKDR | |
| SCHEMBL467659 | 0.79 | AXL (0.49) | AXLHRH3INSRKDR | |
| SCHEMBL467696 | 0.78 | AXL (0.43) | AXLINSRKDR | |
| SCHEMBL467601 | 0.77 | FLT3 (0.36) | AXLGAAINSRKDR | |
| SCHEMBL467833 | 0.76 | AXL (0.47) | AXLHRH3INSRKDR | |
| SCHEMBL27769653 | 0.76 | AXL (0.42) | AXLHRH3INSRKDR | |
| SCHEMBL467749 | 0.76 | AXL (0.40) | AXLINSRKDR | |
| SCHEMBL467792 | 0.75 | AXL (0.44) | AXLHRH3KHKINSRKDR | |
| SCHEMBL18009413 | 0.75 | ALDH1A1 (0.46) | RAD52AXLGAA | |
| SCHEMBL467537 | 0.74 | CHIT1 (0.36) | CHIT1CHIAAXLGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101622246-A | Polycyclic heteroaryl substituted triazoles useful as AXL inhibitors | RIGEL PHARMACEUTICALS INC | 2010-01-06 | — | — | CN | claimed |
| CN-101622246-A | Polycyclic heteroaryl substituted triazoles useful as AXL inhibitors | RIGEL PHARMACEUTICALS INC | 2010-01-06 | — | — | CN | disclosed |