Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.37 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ATP4A | P20648 | 1/20 | 0.31 |
| ▸ | ATP4B | P51164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL252583 | 0.82 | HDAC3 (0.38) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL23166458 | 0.80 | HDAC3 (0.37) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2771532 | 0.80 | RAB9A (0.38) | LMNAKDM4EPOLBNPC1RAB9A | |
| SCHEMBL5566834 | 0.78 | ALOX5 (0.32) | ALOX5LMNAALDH1A1ATP4AATP4B | |
| SCHEMBL1000856 | 0.78 | ALDH1A1 (0.44) | LMNAALDH1A1ATP4AATP4BKDM4E | |
| Hydrochloric Acid SCHEMBL11102564 | 0.77 | ALDH1A1 (0.46) | LMNAALDH1A1ATP4AATP4BKDM4E | |
| SCHEMBL2896809 | 0.77 | HDAC3 (0.38) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL27635816 | 0.77 | ALDH1A1 (0.36) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL9555511 | 0.77 | HDAC1 (0.52) | HDAC1HDAC8HDAC6ALOX5LMNA | |
| SCHEMBL29350255 | 0.76 | MAPT (0.33) | ALOX5ALDH1A1MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113461635-A | 4- (2-chloroethyl) thiazole-2-carboxylic acid ethyl ester and preparation method and application thereof | 上海毕得医药科技股份有限公司 | 2021-10-01 | — | — | CN | disclosed |
| CN-102906093-B | NK-3 receptor selective antagonists compound, pharmaceutical composition and the using method in the receptor-mediated disease of NK-3 | EUROSCREEN S.A. (BE) | 2016-01-13 | — | — | CN | disclosed |
| CN-103582637-B | Tyrosine kinase inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 2015-08-12 | — | — | CN | disclosed |
| CN-104640858-A | Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use | HOFFMANN LA ROCHE | 2015-05-20 | — | — | CN | disclosed |
| CN-104583218-A | Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4(PAR4) inhibitors for the treatment of platelet aggregation | BRISTOL MYERS SQUIBB CO | 2015-04-29 | — | — | CN | disclosed |
| CN-102171196-B | Azole derivatives as inhibitors of fatty acid amide hydrolase | MERCK SHARP & DOHME | 2015-03-25 | — | — | CN | disclosed |
| CN-104411713-A | PAR4 agonist peptides | BRISTOL MYERS SQUIBB CO | 2015-03-11 | — | — | CN | disclosed |
| CN-103582637-A | Tyrosine Kinase Inhibitors | HOFFMANN LA ROCHE | 2014-02-12 | — | — | CN | disclosed |
| CN-103145711-A | Azaadamantane ester and carbamate derivatives and methods of use thereof | ABBOTT LAB | 2013-06-12 | — | — | CN | disclosed |
| CN-102906093-A | Novel nk-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in nk-3 receptors mediated disorders | EUROSCREEN SA | 2013-01-30 | — | — | CN | disclosed |
| CN-101835764-B | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC | 2012-09-19 | — | — | CN | disclosed |
| CN-102516115-A | Novel compounds as antagonists or inverse agonists at opioid receptors | SMITHKLINE BEECHAM CORP | 2012-06-27 | — | — | CN | disclosed |
| CN-102171196-A | Azole derivatives as inhibitors of fatty acid amide hydrolase | MERCK & CO INC | 2011-08-31 | — | — | CN | disclosed |
| CN-102164896-A | Phenethylamide derivatives and their heterocyclic analogues | ACTELION PHARMACEUTICALS LTD | 2011-08-24 | — | — | CN | disclosed |
| CN-102089303-A | Nitrogenated heterocyclic compound | ASAHI KASEI PHARMA CORP | 2011-06-08 | — | — | CN | disclosed |
| CN-102089302-A | Nitrogenated bicyclic heterocyclic compound | ASAHI KASEI PHARMA CORP | 2011-06-08 | — | — | CN | disclosed |
| CN-101965343-A | 2-aza-bicyclo[2.2.1]heptane derivatives | ACTELION PHARMACEUTICALS LTD | 2011-02-02 | — | — | CN | disclosed |
| CN-101835764-A | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC | 2010-09-15 | — | — | CN | disclosed |
| CN-101522614-A | Novel compounds as antagonists or inverse agonists of opioid receptors | SMITHKLINE BEECHAM CORP (US) | 2009-09-02 | — | — | CN | disclosed |
| CN-101454297-A | Aryl-4-ethynyl-isoxazole derivatives | HOFFMANN LA ROCHE (CH) | 2009-06-10 | — | — | CN | disclosed |