Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 3/20 | 0.38 |
| ▸ | NOS2 | P35228 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27543329 | 0.85 | LOXL2 (0.46) | LOXL2ENPP2SIGMAR1NOS1NOS2 | |
| SCHEMBL16274690 | 0.82 | CRHBP (0.46) | LOXL2ENPP2SIGMAR1AOC3NOS1 | |
| SCHEMBL2288489 | 0.82 | LOXL2 (0.46) | LOXL2ENPP2SIGMAR1NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL1868254 | 0.81 | NOS1 (0.45) | LOXL2ENPP2SIGMAR1NOS1NOS2 | |
| SCHEMBL95584 | 0.79 | HSD17B1 (0.51) | SIGMAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL13306211 | 0.78 | LOXL2 (0.54) | LOXL2ENPP2SIGMAR1NOS1NOS2 | |
| SCHEMBL27326764 | 0.77 | KMT2A (0.54) | LOXL2SIGMAR1ALDH1A1SMN1; SMN2OPRM1 | |
| SCHEMBL8279007 | 0.77 | GRM5 (0.45) | LOXL2ENPP2SIGMAR1NOS1NOS2 | |
| SCHEMBL27976614 | 0.76 | SIGMAR1 (0.42) | LOXL2ENPP2SIGMAR1CYP2D6OPRM1 | |
| Hydrochloric Acid SCHEMBL4934804 | 0.76 | GRM5 (0.44) | LOXL2ENPP2SIGMAR1NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101489555-A | Nf-kappa | OTSUKA PHARMA CO LTD (JP) | 2009-07-22 | — | — | CN | disclosed |