Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 7/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.31 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27735035 | 0.92 | GRIA1 (0.38) | GRIA1GRIA3PDE4DPRKCZNR3C2 | |
| SCHEMBL27755573 | 0.91 | GRM5 (0.33) | GRIA1GRIA3PDE4DPRKCZNR3C2 | |
| SCHEMBL27755568 | 0.90 | GRM5 (0.34) | GRIA1GRIA3PDE4DPRKCZNR3C2 | |
| SCHEMBL27580466 | 0.90 | PRKCZ (0.35) | GRIA1GRIA3PDE4DPRKCZGRM5 | |
| SCHEMBL27735021 | 0.88 | ALDH1A1 (0.33) | GRIA1GRIA3PDE4DPRKCZNR3C2 | |
| SCHEMBL27755572 | 0.88 | NPSR1 (0.39) | GRIA1GRIA3PDE4DPRKCZNR3C2 | |
| SCHEMBL27734999 | 0.88 | PRKCZ (0.34) | GRIA1GRIA3PDE4DPRKCZNR3C2 | |
| SCHEMBL27598121 | 0.86 | PIK3CD (0.37) | GRIA1GRIA3PDE4DPRKCZGRM5 | |
| SCHEMBL27755571 | 0.86 | GRM5 (0.33) | GRIA1GRIA3PDE4DPRKCZNR3C2 | |
| SCHEMBL27755569 | 0.85 | PRKCZ (0.36) | PRKCZNR3C2GRM5KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101486683-B | Pyridazinone and triazinone compounds and their use as pharmaceutical formulations | Sanitary Material R&D Management Co.,Ltd. (JP) | 2011-12-21 | — | — | CN | disclosed |
| CN-101486683-A | Pyridazinone and triazinone compounds and their use as pharmaceutical formulations | EISAI R&D MAN CO LTD (JP) | 2009-07-22 | — | — | CN | disclosed |