Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.32 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.32 |
| ▸ | VCP | P55072 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27771612 | 0.91 | GRIA1 (0.38) | GRM5GRIA1GRIA3PDE4DPRKCZ | |
| SCHEMBL27735008 | 0.87 | CYP2A6 (0.34) | CYP2A6PRKCZBRAF | |
| SCHEMBL27735006 | 0.86 | CYP2A6 (0.39) | GRM5CYP2A6PRKCZBRAFCYP11B2 | |
| SCHEMBL27755568 | 0.85 | GRM5 (0.34) | GRM5GRIA1GRIA3PDE4DPRKCZ | |
| SCHEMBL27735035 | 0.85 | GRIA1 (0.38) | GRM5GRIA1GRIA3PDE4DPRKCZ | |
| SCHEMBL27580466 | 0.85 | PRKCZ (0.35) | GRM5GRIA1GRIA3PDE4DPRKCZ | |
| SCHEMBL27735021 | 0.84 | ALDH1A1 (0.33) | GRM5GRIA1GRIA3PDE4DPRKCZ | |
| SCHEMBL27755572 | 0.84 | NPSR1 (0.39) | GRIA1GRIA3PDE4DPIK3CDPRKCZ | |
| SCHEMBL27734999 | 0.83 | PRKCZ (0.34) | GRM5GRIA1GRIA3PDE4DPRKCZ | |
| SCHEMBL27755571 | 0.82 | GRM5 (0.33) | GRM5GRIA1GRIA3PDE4DPRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101486683-B | Pyridazinone and triazinone compounds and their use as pharmaceutical formulations | Sanitary Material R&D Management Co.,Ltd. (JP) | 2011-12-21 | — | — | CN | disclosed |
| CN-101486683-A | Pyridazinone and triazinone compounds and their use as pharmaceutical formulations | EISAI R&D MAN CO LTD (JP) | 2009-07-22 | — | — | CN | disclosed |
| CN-100473647-C | Pyridazinone and triazinone compounds and their use as pharmaceutical formulations | EISAI CO LTD (JP) | 2009-04-01 | — | — | CN | disclosed |