Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.43 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2949575 | 0.95 | ABHD6 (0.44) | ABHD6DAGLANR1H2NR1H3GPR119 | |
| SCHEMBL2946591 | 0.78 | SLC6A4 (0.56) | ABHD6DAGLANR1H2NR1H3PARP1 | |
| SCHEMBL31330650 | 0.77 | ALDH1A1 (0.51) | GPR119RORC | |
| SCHEMBL2946903 | 0.75 | SLC6A4 (0.46) | ABHD6DAGLANR1H2NR1H3GPR119 | |
| SCHEMBL2948211 | 0.75 | SLC6A2 (0.42) | ABHD6DAGLANR1H2NR1H3PARP1 | |
| SCHEMBL31330699 | 0.74 | NPC1 (0.56) | GPR119 | |
| SCHEMBL23854712 | 0.73 | TMEM97 (0.56) | PARP1 | |
| SCHEMBL21800237 | 0.73 | TMEM97 (0.56) | PARP1 | |
| SCHEMBL21591745 | 0.72 | HDAC1 (0.44) | NR1H2GPR119USP30RORC | |
| SCHEMBL8236259 | 0.72 | GPR119 (0.52) | NR1H2GPR119JAK2JAK1SMARCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101501008-B | Arylpiperazine derivatives and uses thereof | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-07 | — | — | CN | disclosed |
| CN-101501008-A | Arylpiperazine derivatives and uses thereof | HOFFMANN LA ROCHE (CH) | 2009-08-05 | — | — | CN | disclosed |