Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28083060 | 0.82 | TGFBR1 (0.48) | NPC1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL26740722 | 0.77 | NPC1 (0.57) | NPC1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL9453979 | 0.77 | ALDH1A1 (0.66) | NPC1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL21130590 | 0.76 | PDCD1 (0.53) | NPC1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL20032697 | 0.76 | ATR (0.41) | NPC1MAPTALDH1A1KMT2AMAPK10 | |
| Hydrochloric Acid SCHEMBL28048607 | 0.75 | ALDH1A1 (0.64) | NPC1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL29966674 | 0.74 | NPC1 (0.63) | NPC1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL29942654 | 0.74 | NPC1 (0.63) | NPC1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL29614829 | 0.74 | NPC1 (0.63) | NPC1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL3076524 | 0.74 | NPC1 (0.63) | NPC1MAPTKDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101678020-A | Quinoxaline derivatives as inhibitors of the tyrosine kinase activity of Janus kinases | NOVARTIS AG | 2010-03-24 | — | — | CN | disclosed |