Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 6/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2777832 | 0.84 | MEN1 (0.52) | MEN1KMT2ALMNAMMP1MMP2 | |
| SCHEMBL30225664 | 0.78 | ALOX15 (0.39) | ALOX15BCHEACHE | |
| SCHEMBL11141256 | 0.77 | MEN1 (0.46) | MEN1KMT2ALMNAMMP1MMP2 | |
| SCHEMBL11626412 | 0.74 | CA12 (0.42) | MEN1KMT2AMMP1MMP2MMP3 | |
| SCHEMBL9849361 | 0.74 | CA12 (0.42) | MEN1KMT2AMMP1MMP2MMP3 | |
| SCHEMBL17040541 | 0.74 | — | — | |
| SCHEMBL19003453 | 0.73 | HSD17B10 (0.46) | MEN1KMT2ALMNAMMP1MMP2 | |
| SCHEMBL5888694 | 0.73 | MEN1 (0.44) | MEN1KMT2AALOX15LMNAMMP1 | |
| SCHEMBL12562589 | 0.71 | MEN1 (0.42) | MEN1KMT2AALOX15LMNAMMP1 | |
| SCHEMBL2778900 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170897-B1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS | UNIV BROCK (CA) | 2013-08-21 | — | — | EP | claimed |
| EP-2170897-A1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS | Brock University (CA) | 2010-04-07 | — | — | EP | claimed |
| WO-2009003270-A1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS | BROCK UNIVERSITY (CA) | 2009-01-08 | — | — | WO | claimed |
| CN-108026032-B | Method for producing optically active 4-carbamoyl-2, 6-dimethylphenylalanine derivative | 株式会社钟化 | 2020-09-29 | — | — | CN | disclosed |
| US-9340550-B2 | Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids | BROCK UNIVERSITY (CA) | 2016-05-17 | — | — | US | disclosed |
| US-20150152120-A1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-FUNCTIONALIZATION OF MORPHINE AND TROPANE ALKALOIDS | BROCK UNIVERSITY (CA) | 2015-06-04 | — | — | US | disclosed |
| US-8962841-B2 | Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids | BROCK UNIVERSITY (CA) | 2015-02-24 | — | — | US | disclosed |
| EP-2170897-B1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS | UNIV BROCK (CA) | 2013-08-21 | — | — | EP | disclosed |
| US-20110313163-A1 | Methods for One-Pot N-Demethylation/N-Functionalization of Morphine and Tropane Alkaloids | BROCK UNIVERSITY (CA) | 2011-12-22 | — | — | US | disclosed |
| EP-2170897-A1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS | Brock University (CA) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009003270-A1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS | BROCK UNIVERSITY (CA) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152120-A1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-FUNCTIONALIZATION OF MORPHINE AND TROPANE ALKALOIDS | PNMT, HNMT, OPRM1 | MEN1 2109/4885KMT2A 223/4885ALOX15 2563/4885 |
| US-20110313163-A1 | Methods for One-Pot N-Demethylation/N-Functionalization of Morphine and Tropane Alkaloids | PNMT, HNMT, OPRM1 | MEN1 2109/4885KMT2A 223/4885ALOX15 2563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.