Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 4/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | UGCG | Q16739 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.30 |
| ▸ | TNF | P01375 | 1/20 | 0.30 |
| ▸ | LITAF | Q99732 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27785942 | 0.97 | GABRG2 (0.42) | GABRG2GABRB3GABRA2LCKBTK | |
| SCHEMBL27785948 | 0.87 | GABRG2 (0.34) | GABRG2GABRB3GABRA2TNFLITAF | |
| SCHEMBL27807929 | 0.85 | PIK3CA (0.34) | GABRG2GABRB3GABRA2TNFLITAF | |
| SCHEMBL27786019 | 0.84 | GABRG2 (0.47) | GABRG2GABRB3GABRA2LCKBTK | |
| SCHEMBL27807942 | 0.84 | PIK3CA (0.42) | GABRG2GABRB3GABRA2BTK | |
| SCHEMBL27785974 | 0.83 | GABRG2 (0.33) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27807931 | 0.83 | PIK3CA (0.43) | GABRG2GABRB3GABRA2BTK | |
| SCHEMBL27807949 | 0.82 | GABRG2 (0.35) | GABRG2GABRB3GABRA2ATR | |
| SCHEMBL27786011 | 0.82 | BRD9 (0.36) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27785937 | 0.80 | ADORA2A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |